SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling

WNT signaling stimulates the self-renewal of many types of adult stem cells, including mammary stem cells (MaSCs), but mechanisms that limit this activity are poorly understood. Here, we demonstrate that SLIT2 restricts stem cell renewal by signaling through ROBO2 in a subset of basal cells to negat...

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Detalles Bibliográficos
Autores principales: Harburg, Gwyndolen, Compton, Jennifer, Liu, Wei, Iwai, Naomi, Zada, Shahrzad, Marlow, Rebecca, Strickland, Phyllis, Zeng, Yi Arial, Hinck, Lindsay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266005/
https://www.ncbi.nlm.nih.gov/pubmed/25241737
http://dx.doi.org/10.1016/j.stemcr.2014.07.007

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