Methylation and Transcripts Expression at the Imprinted GNAS Locus in Human Embryonic and Induced Pluripotent Stem Cells and Their Derivatives

Data from the literature indicate that genomic imprint marks are disturbed in human pluripotent stem cells (PSCs). GNAS is an imprinted locus that produces one biallelic (Gsα) and four monoallelic (NESP55, GNAS-AS1, XLsα, and A/B) transcripts due to differential methylation of their promoters (DMR)....

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Detalles Bibliográficos
Autores principales: Grybek, Virginie, Aubry, Laetitia, Maupetit-Méhouas, Stéphanie, Le Stunff, Catherine, Denis, Cécile, Girard, Mathilde, Linglart, Agnès, Silve, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266011/
https://www.ncbi.nlm.nih.gov/pubmed/25241742
http://dx.doi.org/10.1016/j.stemcr.2014.07.002

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