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Prefrontal cortex hemodynamics and age: a pilot study using functional near infrared spectroscopy in children
Cerebral hemodynamics reflect cognitive processes and underlying physiological processes, both of which are captured by functional near infrared spectroscopy (fNIRS). Here, we introduce a novel parameter of Oxygenation Variability directly obtained from fNIRS data —the OV Index—and we demonstrate it...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266015/ https://www.ncbi.nlm.nih.gov/pubmed/25565935 http://dx.doi.org/10.3389/fnins.2014.00393 |
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author | Anderson, Afrouz A. Smith, Elizabeth Chernomordik, Victor Ardeshirpour, Yasaman Chowdhry, Fatima Thurm, Audrey Black, David Matthews, Dennis Rennert, Owen Gandjbakhche, Amir H. |
author_facet | Anderson, Afrouz A. Smith, Elizabeth Chernomordik, Victor Ardeshirpour, Yasaman Chowdhry, Fatima Thurm, Audrey Black, David Matthews, Dennis Rennert, Owen Gandjbakhche, Amir H. |
author_sort | Anderson, Afrouz A. |
collection | PubMed |
description | Cerebral hemodynamics reflect cognitive processes and underlying physiological processes, both of which are captured by functional near infrared spectroscopy (fNIRS). Here, we introduce a novel parameter of Oxygenation Variability directly obtained from fNIRS data —the OV Index—and we demonstrate its use in children. fNIRS data were collected from 17 children (ages 4–8 years), while they performed a standard Go/No-Go task. Data were analyzed using two frequency bands—the first attributed to cerebral autoregulation (CA) (<0.1 Hz) and the second to respiration (0.2–0.3 Hz). Results indicate differences in variability of oscillations of oxygen saturation (SO(2)) between the two different bands. These pilot data reveal a dynamic relationship between chronological age and OV index in CA associated frequency of <0.1 Hz. Specifically, OV index increased with age between 4 and 6 years. In addition, there was much higher variability in frequencies associated with CA than for respiration across subjects. These findings provide preliminary evidence for the utility of the OV index and are the first to describe the relationship between cerebral autoregulation and age in children using fNIRS methodology. |
format | Online Article Text |
id | pubmed-4266015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42660152015-01-06 Prefrontal cortex hemodynamics and age: a pilot study using functional near infrared spectroscopy in children Anderson, Afrouz A. Smith, Elizabeth Chernomordik, Victor Ardeshirpour, Yasaman Chowdhry, Fatima Thurm, Audrey Black, David Matthews, Dennis Rennert, Owen Gandjbakhche, Amir H. Front Neurosci Neuroscience Cerebral hemodynamics reflect cognitive processes and underlying physiological processes, both of which are captured by functional near infrared spectroscopy (fNIRS). Here, we introduce a novel parameter of Oxygenation Variability directly obtained from fNIRS data —the OV Index—and we demonstrate its use in children. fNIRS data were collected from 17 children (ages 4–8 years), while they performed a standard Go/No-Go task. Data were analyzed using two frequency bands—the first attributed to cerebral autoregulation (CA) (<0.1 Hz) and the second to respiration (0.2–0.3 Hz). Results indicate differences in variability of oscillations of oxygen saturation (SO(2)) between the two different bands. These pilot data reveal a dynamic relationship between chronological age and OV index in CA associated frequency of <0.1 Hz. Specifically, OV index increased with age between 4 and 6 years. In addition, there was much higher variability in frequencies associated with CA than for respiration across subjects. These findings provide preliminary evidence for the utility of the OV index and are the first to describe the relationship between cerebral autoregulation and age in children using fNIRS methodology. Frontiers Media S.A. 2014-12-15 /pmc/articles/PMC4266015/ /pubmed/25565935 http://dx.doi.org/10.3389/fnins.2014.00393 Text en Copyright © 2014 Anderson, Smith, Chernomordik, Ardeshirpour, Chowdhry, Thurm, Black, Matthews, Rennert and Gandjbakhche. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Anderson, Afrouz A. Smith, Elizabeth Chernomordik, Victor Ardeshirpour, Yasaman Chowdhry, Fatima Thurm, Audrey Black, David Matthews, Dennis Rennert, Owen Gandjbakhche, Amir H. Prefrontal cortex hemodynamics and age: a pilot study using functional near infrared spectroscopy in children |
title | Prefrontal cortex hemodynamics and age: a pilot study using functional near infrared spectroscopy in children |
title_full | Prefrontal cortex hemodynamics and age: a pilot study using functional near infrared spectroscopy in children |
title_fullStr | Prefrontal cortex hemodynamics and age: a pilot study using functional near infrared spectroscopy in children |
title_full_unstemmed | Prefrontal cortex hemodynamics and age: a pilot study using functional near infrared spectroscopy in children |
title_short | Prefrontal cortex hemodynamics and age: a pilot study using functional near infrared spectroscopy in children |
title_sort | prefrontal cortex hemodynamics and age: a pilot study using functional near infrared spectroscopy in children |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266015/ https://www.ncbi.nlm.nih.gov/pubmed/25565935 http://dx.doi.org/10.3389/fnins.2014.00393 |
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