Cargando…
YpfΦ: a filamentous phage acquired by Yersinia pestis
Yersinia pestis, the plague bacillus, has an exceptional pathogenicity for humans. The plague bacillus emerged very recently (≈3,000 years ago) from the enteropathogen Y. pseudotuberculosis. Early after its emergence, Y. pestis became infected by a filamentous phage named YpfΦ. During the microevolu...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266046/ https://www.ncbi.nlm.nih.gov/pubmed/25566217 http://dx.doi.org/10.3389/fmicb.2014.00701 |
_version_ | 1782348971503517696 |
---|---|
author | Derbise, Anne Carniel, Elisabeth |
author_facet | Derbise, Anne Carniel, Elisabeth |
author_sort | Derbise, Anne |
collection | PubMed |
description | Yersinia pestis, the plague bacillus, has an exceptional pathogenicity for humans. The plague bacillus emerged very recently (≈3,000 years ago) from the enteropathogen Y. pseudotuberculosis. Early after its emergence, Y. pestis became infected by a filamentous phage named YpfΦ. During the microevolution of the plague bacillus, the phage remained in the various lineages as an unstable extrachromosomal element. However, in the sub branch that caused the third plague pandemic, YpfΦ integrated itself into the bacterial chromosome to become a stable prophage. The genome of this phage has the same genetic organization as that of other filamentous phages such as the Vibrio cholerae CTXΦ phage, and shares high sequence identity with the CUS-1 filamentous phage of a high-virulence Escherichia coli K1 clone. In addition to genes involved in phage physiology, YpfΦ carries at each extremity of its genome two open reading frames with no predicted functions. This filamentous phage confers some selective properties to Y. pestis during the infectious process, which may explain why it was conserved duringY. pestis microevolution, despite its instability as an extrachromosomal element in most branches. |
format | Online Article Text |
id | pubmed-4266046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42660462015-01-06 YpfΦ: a filamentous phage acquired by Yersinia pestis Derbise, Anne Carniel, Elisabeth Front Microbiol Microbiology Yersinia pestis, the plague bacillus, has an exceptional pathogenicity for humans. The plague bacillus emerged very recently (≈3,000 years ago) from the enteropathogen Y. pseudotuberculosis. Early after its emergence, Y. pestis became infected by a filamentous phage named YpfΦ. During the microevolution of the plague bacillus, the phage remained in the various lineages as an unstable extrachromosomal element. However, in the sub branch that caused the third plague pandemic, YpfΦ integrated itself into the bacterial chromosome to become a stable prophage. The genome of this phage has the same genetic organization as that of other filamentous phages such as the Vibrio cholerae CTXΦ phage, and shares high sequence identity with the CUS-1 filamentous phage of a high-virulence Escherichia coli K1 clone. In addition to genes involved in phage physiology, YpfΦ carries at each extremity of its genome two open reading frames with no predicted functions. This filamentous phage confers some selective properties to Y. pestis during the infectious process, which may explain why it was conserved duringY. pestis microevolution, despite its instability as an extrachromosomal element in most branches. Frontiers Media S.A. 2014-12-15 /pmc/articles/PMC4266046/ /pubmed/25566217 http://dx.doi.org/10.3389/fmicb.2014.00701 Text en Copyright © 2014 Derbise and Carniel. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Derbise, Anne Carniel, Elisabeth YpfΦ: a filamentous phage acquired by Yersinia pestis |
title | YpfΦ: a filamentous phage acquired by Yersinia pestis |
title_full | YpfΦ: a filamentous phage acquired by Yersinia pestis |
title_fullStr | YpfΦ: a filamentous phage acquired by Yersinia pestis |
title_full_unstemmed | YpfΦ: a filamentous phage acquired by Yersinia pestis |
title_short | YpfΦ: a filamentous phage acquired by Yersinia pestis |
title_sort | ypfφ: a filamentous phage acquired by yersinia pestis |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266046/ https://www.ncbi.nlm.nih.gov/pubmed/25566217 http://dx.doi.org/10.3389/fmicb.2014.00701 |
work_keys_str_mv | AT derbiseanne ypfphafilamentousphageacquiredbyyersiniapestis AT carnielelisabeth ypfphafilamentousphageacquiredbyyersiniapestis |