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Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants

A new delivery method via polymeric implants was used for continuous exposure to PCBs. Female Sprague-Dawley rats received subcutaneous polymeric implants containing PCB126 (0.15% load), PCB153 (5% load), or both, for up to 45 d and release kinetics and tissue distribution were measured. PCB153 tiss...

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Detalles Bibliográficos
Autores principales:	Aqil, Farrukh, Shen, Hua, Jeyabalan, Jeyaprakash, Xin, Xing, Lehmler, Hans-Joachim, Ludewig, Gabriele, Robertson, Larry W., Gupta, Ramesh C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266188/ https://www.ncbi.nlm.nih.gov/pubmed/25530946 http://dx.doi.org/10.1016/j.toxrep.2014.09.010

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