Persistent Infection by HSV-1 Is Associated With Changes in Functional Architecture of iPSC-Derived Neurons and Brain Activation Patterns Underlying Working Memory Performance

BACKGROUND: Herpes simplex virus, type 1 (HSV-1) commonly produces lytic mucosal lesions. It invariably initiates latent infection in sensory ganglia enabling persistent, lifelong infection. Acute HSV-1 encephalitis is rare and definitive evidence of latent infection in the brain is lacking. However...

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Detalles Bibliográficos
Autores principales: D’Aiuto, Leonardo, Prasad, Konasale M., Upton, Catherine H., Viggiano, Luigi, Milosevic, Jadranka, Raimondi, Giorgio, McClain, Lora, Chowdari, Kodavali, Tischfield, Jay, Sheldon, Michael, Moore, Jennifer C., Yolken, Robert H., Kinchington, Paul R., Nimgaonkar, Vishwajit L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266288/
https://www.ncbi.nlm.nih.gov/pubmed/24622295
http://dx.doi.org/10.1093/schbul/sbu032

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