Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

[Image: see text] The c-jun N-terminal kinase 3 (JNK3) is expressed primarily in the brain. Numerous reports have shown that inhibition of JNK3 is a promising strategy for treatment of neurodegeneration. The optimization of aminopyrazole-based JNK3 inhibitors with improved potency, isoform selectivi...

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Detalles Bibliográficos
Autores principales: Zheng, Ke, Iqbal, Sarah, Hernandez, Pamela, Park, HaJeung, LoGrasso, Philip V., Feng, Yangbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266361/
https://www.ncbi.nlm.nih.gov/pubmed/25393557
http://dx.doi.org/10.1021/jm501256y

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