Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations

Nano-sized particles are known to interfere with drug-metabolizing cytochrome P450 (CYP) enzymes, which can be anticipated to be a potential source of unintended adverse reactions, but the mechanisms underlying the inhibition are still not well understood. Herein we report a systematic investigation...

Descripción completa

Detalles Bibliográficos
Autores principales: Ye, Meiling, Tang, Ling, Luo, Mengjun, Zhou, Jing, Guo, Bin, Liu, Yangyuan, Chen, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2014
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266508/
https://www.ncbi.nlm.nih.gov/pubmed/25520592
http://dx.doi.org/10.1186/1556-276X-9-642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266508/
https://www.ncbi.nlm.nih.gov/pubmed/25520592
http://dx.doi.org/10.1186/1556-276X-9-642

Ejemplares similares