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Hepatic Farnesoid X-Receptor Isoforms α2 and α4 Differentially Modulate Bile Salt and Lipoprotein Metabolism in Mice

The nuclear receptor FXR acts as an intracellular bile salt sensor that regulates synthesis and transport of bile salts within their enterohepatic circulation. In addition, FXR is involved in control of a variety of crucial metabolic pathways. Four FXR splice variants are known, i.e. FXRα1-4. Althou...

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Detalles Bibliográficos
Autores principales:	Boesjes, Marije, Bloks, Vincent W., Hageman, Jurre, Bos, Trijnie, van Dijk, Theo H., Havinga, Rick, Wolters, Henk, Jonker, Johan W., Kuipers, Folkert, Groen, Albert K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266635/ https://www.ncbi.nlm.nih.gov/pubmed/25506828 http://dx.doi.org/10.1371/journal.pone.0115028

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