Amino Alcohol- (NPS-2143) and Quinazolinone-Derived Calcilytics (ATF936 and AXT914) Differentially Mitigate Excessive Signalling of Calcium-Sensing Receptor Mutants Causing Bartter Syndrome Type 5 and Autosomal Dominant Hypocalcemia

INTRODUCTION: Activating calcium sensing receptor (CaSR) mutations cause autosomal dominant hypocalcemia (ADH) characterized by low serum calcium, inappropriately low PTH and relative hypercalciuria. Four activating CaSR mutations cause additional renal wasting of sodium, chloride and other salts, a...

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Detalles Bibliográficos
Autores principales: Letz, Saskia, Haag, Christine, Schulze, Egbert, Frank-Raue, Karin, Raue, Friedhelm, Hofner, Benjamin, Mayr, Bernhard, Schöfl, Christof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266668/
https://www.ncbi.nlm.nih.gov/pubmed/25506941
http://dx.doi.org/10.1371/journal.pone.0115178

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