Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities

Fatty acid synthesis and oxidation are frequently exacerbated in leukemia cells, and may therefore represent a target for therapeutic intervention. In this work we analyzed the apoptotic and chemo-sensitizing action of the fatty acid oxidation inhibitor etomoxir in human acute myeloid leukemia cells...

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Detalles Bibliográficos
Autores principales: Estañ, María Cristina, Calviño, Eva, Calvo, Susana, Guillén-Guío, Beatriz, Boyano-Adánez, María del Carmen, de Blas, Elena, Rial, Eduardo, Aller, Patricio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266683/
https://www.ncbi.nlm.nih.gov/pubmed/25506699
http://dx.doi.org/10.1371/journal.pone.0115250

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