Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production

Drug resistance is a problem wherever livestock are raised under intensive conditions and drugs are used to combat parasitic infections. This is particularly true for the anticoccidial agents used for the prevention of coccidiosis caused by protozoa of the apicomplexan genus Eimeria in poultry. Resi...

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Autores principales: Chapman, H. David, Jeffers, Thomas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266793/
https://www.ncbi.nlm.nih.gov/pubmed/25516830
http://dx.doi.org/10.1016/j.ijpddr.2014.10.002
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author Chapman, H. David
Jeffers, Thomas K.
author_facet Chapman, H. David
Jeffers, Thomas K.
author_sort Chapman, H. David
collection PubMed
description Drug resistance is a problem wherever livestock are raised under intensive conditions and drugs are used to combat parasitic infections. This is particularly true for the anticoccidial agents used for the prevention of coccidiosis caused by protozoa of the apicomplexan genus Eimeria in poultry. Resistance has been documented for all the dozen or so drugs approved for use in chickens and varying levels of resistance is present for those currently employed. A possible solution may be the introduction of drug-sensitive parasites into the houses where poultry are raised so that they may replace such drug-resistant organisms. This can be achieved by utilizing live vaccines that contain strains of Eimeria that were isolated before most anticoccidial compounds were introduced. Such strains are inherently drug-sensitive. Practical proposals to achieve this objective involve the alternation of vaccination with medication (known as rotation programs) in successive flocks reared in the same poultry house. A proposal for a yearly broiler production cycle involving chemotherapy and vaccination is presented. There are few, if any, examples in veterinary parasitology where it has proved possible to restore sensitivity to drugs used to control a widespread parasite. Further research is necessary to ascertain whether this can result in sustainable and long-term control of Eimeria infections in poultry.
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spelling pubmed-42667932014-12-16 Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production Chapman, H. David Jeffers, Thomas K. Int J Parasitol Drugs Drug Resist Current Opinion Drug resistance is a problem wherever livestock are raised under intensive conditions and drugs are used to combat parasitic infections. This is particularly true for the anticoccidial agents used for the prevention of coccidiosis caused by protozoa of the apicomplexan genus Eimeria in poultry. Resistance has been documented for all the dozen or so drugs approved for use in chickens and varying levels of resistance is present for those currently employed. A possible solution may be the introduction of drug-sensitive parasites into the houses where poultry are raised so that they may replace such drug-resistant organisms. This can be achieved by utilizing live vaccines that contain strains of Eimeria that were isolated before most anticoccidial compounds were introduced. Such strains are inherently drug-sensitive. Practical proposals to achieve this objective involve the alternation of vaccination with medication (known as rotation programs) in successive flocks reared in the same poultry house. A proposal for a yearly broiler production cycle involving chemotherapy and vaccination is presented. There are few, if any, examples in veterinary parasitology where it has proved possible to restore sensitivity to drugs used to control a widespread parasite. Further research is necessary to ascertain whether this can result in sustainable and long-term control of Eimeria infections in poultry. Elsevier 2014-10-25 /pmc/articles/PMC4266793/ /pubmed/25516830 http://dx.doi.org/10.1016/j.ijpddr.2014.10.002 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Current Opinion
Chapman, H. David
Jeffers, Thomas K.
Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production
title Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production
title_full Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production
title_fullStr Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production
title_full_unstemmed Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production
title_short Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production
title_sort vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production
topic Current Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266793/
https://www.ncbi.nlm.nih.gov/pubmed/25516830
http://dx.doi.org/10.1016/j.ijpddr.2014.10.002
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