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Development of a standardized method for contouring the larynx and its substructures
OBJECTIVES: Limiting radiation dose to the larynx can diminish effects of laryngeal dysfunction. However, no clear guidelines exist for defining the larynx and its substructures consistently on cross-sectional imaging. This study presents computed tomography (CT)- and magnetic resonance imaging (MRI...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266916/ https://www.ncbi.nlm.nih.gov/pubmed/25499048 http://dx.doi.org/10.1186/s13014-014-0285-4 |
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author | Choi, Mehee Refaat, Tamer Lester, Malisa S Bacchus, Ian Rademaker, Alfred W Mittal, Bharat B |
author_facet | Choi, Mehee Refaat, Tamer Lester, Malisa S Bacchus, Ian Rademaker, Alfred W Mittal, Bharat B |
author_sort | Choi, Mehee |
collection | PubMed |
description | OBJECTIVES: Limiting radiation dose to the larynx can diminish effects of laryngeal dysfunction. However, no clear guidelines exist for defining the larynx and its substructures consistently on cross-sectional imaging. This study presents computed tomography (CT)- and magnetic resonance imaging (MRI)-based guidelines for contouring laryngeal organs-at-risk (OARs). MATERIALS AND METHODS: Standardized guidelines for delineating laryngeal OARs were devised and used to delineate on CT and MRI for head-and-neck cancer patients. Volumetric comparisons were performed to evaluate consistency and reproducibility of guideline-based contours. RESULTS: For the initial 5 patients the mean CT and MRI based larynx volume did not differ significantly between imaging modalities; 34.39 ± 9.85 vs. 35.01 ± 9.47 (p = .09). There was no statistical difference between the CT based mean laryngeal volume in the subsequent 44 patients compared to the initial 5 patients outlined on CT and the MRI scan (p = 0.53 and 0.62). The OAR volume for laryngeal substructures were not statistically different among patients or between imaging modalities. Once established, the guidelines were easy to follow. CONCLUSION: The guidelines developed provide a precise method for delineating laryngeal OARs. These guidelines need to be validated and clinical significance of outlining laryngeal substructures and dose-volume constraints should be investigated before routine implementation in clinic practice. |
format | Online Article Text |
id | pubmed-4266916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42669162014-12-16 Development of a standardized method for contouring the larynx and its substructures Choi, Mehee Refaat, Tamer Lester, Malisa S Bacchus, Ian Rademaker, Alfred W Mittal, Bharat B Radiat Oncol Research OBJECTIVES: Limiting radiation dose to the larynx can diminish effects of laryngeal dysfunction. However, no clear guidelines exist for defining the larynx and its substructures consistently on cross-sectional imaging. This study presents computed tomography (CT)- and magnetic resonance imaging (MRI)-based guidelines for contouring laryngeal organs-at-risk (OARs). MATERIALS AND METHODS: Standardized guidelines for delineating laryngeal OARs were devised and used to delineate on CT and MRI for head-and-neck cancer patients. Volumetric comparisons were performed to evaluate consistency and reproducibility of guideline-based contours. RESULTS: For the initial 5 patients the mean CT and MRI based larynx volume did not differ significantly between imaging modalities; 34.39 ± 9.85 vs. 35.01 ± 9.47 (p = .09). There was no statistical difference between the CT based mean laryngeal volume in the subsequent 44 patients compared to the initial 5 patients outlined on CT and the MRI scan (p = 0.53 and 0.62). The OAR volume for laryngeal substructures were not statistically different among patients or between imaging modalities. Once established, the guidelines were easy to follow. CONCLUSION: The guidelines developed provide a precise method for delineating laryngeal OARs. These guidelines need to be validated and clinical significance of outlining laryngeal substructures and dose-volume constraints should be investigated before routine implementation in clinic practice. BioMed Central 2014-12-11 /pmc/articles/PMC4266916/ /pubmed/25499048 http://dx.doi.org/10.1186/s13014-014-0285-4 Text en © Choi et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Choi, Mehee Refaat, Tamer Lester, Malisa S Bacchus, Ian Rademaker, Alfred W Mittal, Bharat B Development of a standardized method for contouring the larynx and its substructures |
title | Development of a standardized method for contouring the larynx and its substructures |
title_full | Development of a standardized method for contouring the larynx and its substructures |
title_fullStr | Development of a standardized method for contouring the larynx and its substructures |
title_full_unstemmed | Development of a standardized method for contouring the larynx and its substructures |
title_short | Development of a standardized method for contouring the larynx and its substructures |
title_sort | development of a standardized method for contouring the larynx and its substructures |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266916/ https://www.ncbi.nlm.nih.gov/pubmed/25499048 http://dx.doi.org/10.1186/s13014-014-0285-4 |
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