Cargando…
Evaluation of postextraction bleeding incidence to compare patients receiving and not receiving warfarin therapy: a cross-sectional, multicentre, observational study
OBJECTIVES: We investigated incidence and risk factors for postextraction bleeding in patients receiving warfarin and those not receiving anticoagulation therapy. DESIGN: Cross-sectional, multicentre, observational study. SETTING: 26 hospitals where an oral surgeon is available. PARTICIPANTS: Data o...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267073/ https://www.ncbi.nlm.nih.gov/pubmed/25510886 http://dx.doi.org/10.1136/bmjopen-2014-005777 |
_version_ | 1782349095221854208 |
---|---|
author | Iwabuchi, Hiroshi Imai, Yutaka Asanami, Soichiro Shirakawa, Masayori Yamane, Gen-yuki Ogiuchi, Hideki Kurashina, Kenji Miyata, Masaru Nakao, Hiroyuki Imai, Hirohisa |
author_facet | Iwabuchi, Hiroshi Imai, Yutaka Asanami, Soichiro Shirakawa, Masayori Yamane, Gen-yuki Ogiuchi, Hideki Kurashina, Kenji Miyata, Masaru Nakao, Hiroyuki Imai, Hirohisa |
author_sort | Iwabuchi, Hiroshi |
collection | PubMed |
description | OBJECTIVES: We investigated incidence and risk factors for postextraction bleeding in patients receiving warfarin and those not receiving anticoagulation therapy. DESIGN: Cross-sectional, multicentre, observational study. SETTING: 26 hospitals where an oral surgeon is available. PARTICIPANTS: Data on 2817 teeth (from 496 patients receiving warfarin, 2321 patients not receiving warfarin; mean age (SD): 62.2 (17.6)) extracted between 1 November 2008 and 31 March 2010, were collected. Warfarin-receiving patients were eligible when prothrombin time–international normalised ratio (PT-INR) measured within 7 days prior to the extraction was less than 3.0. INTERVENTIONS: Simple dental extraction was performed, and incidence of postextraction bleeding and comorbidities were recorded. PRIMARY AND SECONDARY OUTCOME MEASURES: Postextraction bleeding not controlled by basic haemostasis procedure was clinically significant. RESULTS: Bleeding events were reported for 35 (7.1%) and 49 (2.1%) teeth, of which 18 (3.6%) and 9 (0.4%) teeth were considered clinically significant, in warfarin and non-warfarin groups, respectively, the difference between which was 3.24% (CI 1.58% to 4.90%). The incidence rates by patients were 2.77% and 0.39%, in warfarin and non-warfarin groups, respectively (incidence difference 2.38%, CI 0.65% to 4/10%). Univariate analyses showed that age (OR 0.197, p=0.001), PT-INR (OR 3.635, p=0.003), mandibular foramen conduction anaesthesia (OR 4.854, p=0.050) and formation of abnormal granulation tissue in extraction socket (OR 2.900, p=0.031) significantly correlate with bleeding incidence. Multivariate analysis revealed that age (OR 0.126, p=0.001), antiplatelet drugs (OR 0.100, p=0.049), PT-INR (OR 7.797, p=0.001) and history of acute inflammation at extraction site (OR 3.722, p=0.037) were significant risk factors for postextraction bleeding. CONCLUSIONS: Our results suggest that there is slight but significant increase in the incidences of postextraction bleeding in patients receiving warfarin. Although absolute incidence was low in both groups, the bleeding risk is not negligible. |
format | Online Article Text |
id | pubmed-4267073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-42670732014-12-18 Evaluation of postextraction bleeding incidence to compare patients receiving and not receiving warfarin therapy: a cross-sectional, multicentre, observational study Iwabuchi, Hiroshi Imai, Yutaka Asanami, Soichiro Shirakawa, Masayori Yamane, Gen-yuki Ogiuchi, Hideki Kurashina, Kenji Miyata, Masaru Nakao, Hiroyuki Imai, Hirohisa BMJ Open Dentistry and Oral Medicine OBJECTIVES: We investigated incidence and risk factors for postextraction bleeding in patients receiving warfarin and those not receiving anticoagulation therapy. DESIGN: Cross-sectional, multicentre, observational study. SETTING: 26 hospitals where an oral surgeon is available. PARTICIPANTS: Data on 2817 teeth (from 496 patients receiving warfarin, 2321 patients not receiving warfarin; mean age (SD): 62.2 (17.6)) extracted between 1 November 2008 and 31 March 2010, were collected. Warfarin-receiving patients were eligible when prothrombin time–international normalised ratio (PT-INR) measured within 7 days prior to the extraction was less than 3.0. INTERVENTIONS: Simple dental extraction was performed, and incidence of postextraction bleeding and comorbidities were recorded. PRIMARY AND SECONDARY OUTCOME MEASURES: Postextraction bleeding not controlled by basic haemostasis procedure was clinically significant. RESULTS: Bleeding events were reported for 35 (7.1%) and 49 (2.1%) teeth, of which 18 (3.6%) and 9 (0.4%) teeth were considered clinically significant, in warfarin and non-warfarin groups, respectively, the difference between which was 3.24% (CI 1.58% to 4.90%). The incidence rates by patients were 2.77% and 0.39%, in warfarin and non-warfarin groups, respectively (incidence difference 2.38%, CI 0.65% to 4/10%). Univariate analyses showed that age (OR 0.197, p=0.001), PT-INR (OR 3.635, p=0.003), mandibular foramen conduction anaesthesia (OR 4.854, p=0.050) and formation of abnormal granulation tissue in extraction socket (OR 2.900, p=0.031) significantly correlate with bleeding incidence. Multivariate analysis revealed that age (OR 0.126, p=0.001), antiplatelet drugs (OR 0.100, p=0.049), PT-INR (OR 7.797, p=0.001) and history of acute inflammation at extraction site (OR 3.722, p=0.037) were significant risk factors for postextraction bleeding. CONCLUSIONS: Our results suggest that there is slight but significant increase in the incidences of postextraction bleeding in patients receiving warfarin. Although absolute incidence was low in both groups, the bleeding risk is not negligible. BMJ Publishing Group 2014-12-13 /pmc/articles/PMC4267073/ /pubmed/25510886 http://dx.doi.org/10.1136/bmjopen-2014-005777 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Dentistry and Oral Medicine Iwabuchi, Hiroshi Imai, Yutaka Asanami, Soichiro Shirakawa, Masayori Yamane, Gen-yuki Ogiuchi, Hideki Kurashina, Kenji Miyata, Masaru Nakao, Hiroyuki Imai, Hirohisa Evaluation of postextraction bleeding incidence to compare patients receiving and not receiving warfarin therapy: a cross-sectional, multicentre, observational study |
title | Evaluation of postextraction bleeding incidence to compare patients receiving and not receiving warfarin therapy: a cross-sectional, multicentre, observational study |
title_full | Evaluation of postextraction bleeding incidence to compare patients receiving and not receiving warfarin therapy: a cross-sectional, multicentre, observational study |
title_fullStr | Evaluation of postextraction bleeding incidence to compare patients receiving and not receiving warfarin therapy: a cross-sectional, multicentre, observational study |
title_full_unstemmed | Evaluation of postextraction bleeding incidence to compare patients receiving and not receiving warfarin therapy: a cross-sectional, multicentre, observational study |
title_short | Evaluation of postextraction bleeding incidence to compare patients receiving and not receiving warfarin therapy: a cross-sectional, multicentre, observational study |
title_sort | evaluation of postextraction bleeding incidence to compare patients receiving and not receiving warfarin therapy: a cross-sectional, multicentre, observational study |
topic | Dentistry and Oral Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267073/ https://www.ncbi.nlm.nih.gov/pubmed/25510886 http://dx.doi.org/10.1136/bmjopen-2014-005777 |
work_keys_str_mv | AT iwabuchihiroshi evaluationofpostextractionbleedingincidencetocomparepatientsreceivingandnotreceivingwarfarintherapyacrosssectionalmulticentreobservationalstudy AT imaiyutaka evaluationofpostextractionbleedingincidencetocomparepatientsreceivingandnotreceivingwarfarintherapyacrosssectionalmulticentreobservationalstudy AT asanamisoichiro evaluationofpostextractionbleedingincidencetocomparepatientsreceivingandnotreceivingwarfarintherapyacrosssectionalmulticentreobservationalstudy AT shirakawamasayori evaluationofpostextractionbleedingincidencetocomparepatientsreceivingandnotreceivingwarfarintherapyacrosssectionalmulticentreobservationalstudy AT yamanegenyuki evaluationofpostextractionbleedingincidencetocomparepatientsreceivingandnotreceivingwarfarintherapyacrosssectionalmulticentreobservationalstudy AT ogiuchihideki evaluationofpostextractionbleedingincidencetocomparepatientsreceivingandnotreceivingwarfarintherapyacrosssectionalmulticentreobservationalstudy AT kurashinakenji evaluationofpostextractionbleedingincidencetocomparepatientsreceivingandnotreceivingwarfarintherapyacrosssectionalmulticentreobservationalstudy AT miyatamasaru evaluationofpostextractionbleedingincidencetocomparepatientsreceivingandnotreceivingwarfarintherapyacrosssectionalmulticentreobservationalstudy AT nakaohiroyuki evaluationofpostextractionbleedingincidencetocomparepatientsreceivingandnotreceivingwarfarintherapyacrosssectionalmulticentreobservationalstudy AT imaihirohisa evaluationofpostextractionbleedingincidencetocomparepatientsreceivingandnotreceivingwarfarintherapyacrosssectionalmulticentreobservationalstudy |