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Increasing proportion of female patients with ankylosing spondylitis: a population-based study of trends in the incidence and prevalence of AS
OBJECTIVE: With the introduction of MRI in diagnosis and tumour necrosis factor inhibitors for treatment, the field of ankylosing spondylitis (AS) has undergone significant changes. We carried out a population-based study of the trends in incidence and prevalence of AS over the past 15 years. METHOD...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267076/ https://www.ncbi.nlm.nih.gov/pubmed/25510888 http://dx.doi.org/10.1136/bmjopen-2014-006634 |
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author | Haroon, Nisha N Paterson, J Michael Li, Ping Haroon, Nigil |
author_facet | Haroon, Nisha N Paterson, J Michael Li, Ping Haroon, Nigil |
author_sort | Haroon, Nisha N |
collection | PubMed |
description | OBJECTIVE: With the introduction of MRI in diagnosis and tumour necrosis factor inhibitors for treatment, the field of ankylosing spondylitis (AS) has undergone significant changes. We carried out a population-based study of the trends in incidence and prevalence of AS over the past 15 years. METHODS: This is a retrospective analysis of provincial health administrative databases. Residents of Ontario, Canada aged 15 years or older diagnosed with AS between 1995 and 2010 were included in the study. Crude as well as age-standardised and sex-standardised incidence and prevalence of AS between 1995 and 2010 were calculated. Trends in prevalence and incidence of male and female patients with AS were separately analysed. RESULTS: We identified 24 976 Ontarians with AS. Age/sex-standardised AS prevalence increased from 79/100 000 in 1995 to 213/100 000 in 2010. Men had higher prevalence than women, but the male/female prevalence ratio decreased from 1.70 in 1995 to 1.21 by 2010. A higher proportion of male compared with female patients with AS were diagnosed in the 15–45 age group. Annual incidence rates revealed increasing diagnosis of AS among women after 2003. CONCLUSIONS: The prevalence of AS in Ontario has nearly tripled over the past two decades. The proportion of women with new diagnosis of AS is increasing, a trend that began around the year 2003. A higher proportion of male compared with female patients with AS are diagnosed at an earlier age. |
format | Online Article Text |
id | pubmed-4267076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-42670762014-12-18 Increasing proportion of female patients with ankylosing spondylitis: a population-based study of trends in the incidence and prevalence of AS Haroon, Nisha N Paterson, J Michael Li, Ping Haroon, Nigil BMJ Open Rheumatology OBJECTIVE: With the introduction of MRI in diagnosis and tumour necrosis factor inhibitors for treatment, the field of ankylosing spondylitis (AS) has undergone significant changes. We carried out a population-based study of the trends in incidence and prevalence of AS over the past 15 years. METHODS: This is a retrospective analysis of provincial health administrative databases. Residents of Ontario, Canada aged 15 years or older diagnosed with AS between 1995 and 2010 were included in the study. Crude as well as age-standardised and sex-standardised incidence and prevalence of AS between 1995 and 2010 were calculated. Trends in prevalence and incidence of male and female patients with AS were separately analysed. RESULTS: We identified 24 976 Ontarians with AS. Age/sex-standardised AS prevalence increased from 79/100 000 in 1995 to 213/100 000 in 2010. Men had higher prevalence than women, but the male/female prevalence ratio decreased from 1.70 in 1995 to 1.21 by 2010. A higher proportion of male compared with female patients with AS were diagnosed in the 15–45 age group. Annual incidence rates revealed increasing diagnosis of AS among women after 2003. CONCLUSIONS: The prevalence of AS in Ontario has nearly tripled over the past two decades. The proportion of women with new diagnosis of AS is increasing, a trend that began around the year 2003. A higher proportion of male compared with female patients with AS are diagnosed at an earlier age. BMJ Publishing Group 2014-12-13 /pmc/articles/PMC4267076/ /pubmed/25510888 http://dx.doi.org/10.1136/bmjopen-2014-006634 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Rheumatology Haroon, Nisha N Paterson, J Michael Li, Ping Haroon, Nigil Increasing proportion of female patients with ankylosing spondylitis: a population-based study of trends in the incidence and prevalence of AS |
title | Increasing proportion of female patients with ankylosing spondylitis: a population-based study of trends in the incidence and prevalence of AS |
title_full | Increasing proportion of female patients with ankylosing spondylitis: a population-based study of trends in the incidence and prevalence of AS |
title_fullStr | Increasing proportion of female patients with ankylosing spondylitis: a population-based study of trends in the incidence and prevalence of AS |
title_full_unstemmed | Increasing proportion of female patients with ankylosing spondylitis: a population-based study of trends in the incidence and prevalence of AS |
title_short | Increasing proportion of female patients with ankylosing spondylitis: a population-based study of trends in the incidence and prevalence of AS |
title_sort | increasing proportion of female patients with ankylosing spondylitis: a population-based study of trends in the incidence and prevalence of as |
topic | Rheumatology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267076/ https://www.ncbi.nlm.nih.gov/pubmed/25510888 http://dx.doi.org/10.1136/bmjopen-2014-006634 |
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