DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity

DOCK8 mutations result in an inherited combined immunodeficiency characterized by increased susceptibility to skin and other infections. We show that when DOCK8-deficient T and NK cells migrate through confined spaces, they develop cell shape and nuclear deformation abnormalities that do not impair...

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Detalles Bibliográficos
Autores principales: Zhang, Qian, Dove, Christopher G., Hor, Jyh Liang, Murdock, Heardley M., Strauss-Albee, Dara M., Garcia, Jordan A., Mandl, Judith N., Grodick, Rachael A., Jing, Huie, Chandler-Brown, Devon B., Lenardo, Timothy E., Crawford, Greg, Matthews, Helen F., Freeman, Alexandra F., Cornall, Richard J., Germain, Ronald N., Mueller, Scott N., Su, Helen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267229/
https://www.ncbi.nlm.nih.gov/pubmed/25422492
http://dx.doi.org/10.1084/jem.20141307

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