Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

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Age-related aggregation of amyloid-β (Aβ) is an upstream pathological event in Alzheimer’s disease (AD) pathogenesis, and it disrupts the sleep–wake cycle. The amount of sleep declines with aging and to a greater extent in AD. Poor sleep quality and insufficient amounts of sleep have been noted in h...

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Detalles Bibliográficos
Autores principales: Roh, Jee Hoon, Jiang, Hong, Finn, Mary Beth, Stewart, Floy R., Mahan, Thomas E., Cirrito, John R., Heda, Ashish, Snider, B. Joy, Li, Mingjie, Yanagisawa, Masashi, de Lecea, Luis, Holtzman, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267230/
https://www.ncbi.nlm.nih.gov/pubmed/25422493
http://dx.doi.org/10.1084/jem.20141788

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