Alternatively spliced transcripts and novel pseudogenes of the Plasmodium falciparum resistance-associated locus pfcrt detected in East African malaria patients

OBJECTIVES: Polymorphisms in the lysosomal transporter encoded by the pfcrt gene directly impact on Plasmodium falciparum susceptibility to aminoquinolines. The Lys76Thr mutation is the critical change conferring chloroquine resistance in vitro and in vivo, but always occurs with additional non-syno...

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Detalles Bibliográficos
Autores principales: Gadalla, Nahla B., Malmberg, Maja, Adam, Ishag, Oguike, Mary C., Beshir, Khalid, Elzaki, Salah-Eldin, Mukhtar, Izdihar, Gadalla, Amal A., Warhurst, David C., Ngasala, Billy, Mårtensson, Andreas, El-Sayed, Badria B., Gil, J. Pedro, Sutherland, Colin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267505/
https://www.ncbi.nlm.nih.gov/pubmed/25253286
http://dx.doi.org/10.1093/jac/dku358

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