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Association of Per3 length polymorphism with bipolar I disorder and schizophrenia

BACKGROUND: Sleep–wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-...

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Autores principales: Karthikeyan, Ramanujam, Marimuthu, Ganapathy, Ramasubramanian, Chellamuthu, Arunachal, Gautham, BaHammam, Ahmed S, Spence, David Warren, Cardinali, Daniel P, Brown, Gregory M, Pandi-Perumal, Seithikurippu R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267513/
https://www.ncbi.nlm.nih.gov/pubmed/25525361
http://dx.doi.org/10.2147/NDT.S73765
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author Karthikeyan, Ramanujam
Marimuthu, Ganapathy
Ramasubramanian, Chellamuthu
Arunachal, Gautham
BaHammam, Ahmed S
Spence, David Warren
Cardinali, Daniel P
Brown, Gregory M
Pandi-Perumal, Seithikurippu R
author_facet Karthikeyan, Ramanujam
Marimuthu, Ganapathy
Ramasubramanian, Chellamuthu
Arunachal, Gautham
BaHammam, Ahmed S
Spence, David Warren
Cardinali, Daniel P
Brown, Gregory M
Pandi-Perumal, Seithikurippu R
author_sort Karthikeyan, Ramanujam
collection PubMed
description BACKGROUND: Sleep–wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08–2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ(2)=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. CONCLUSION: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group.
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spelling pubmed-42675132014-12-18 Association of Per3 length polymorphism with bipolar I disorder and schizophrenia Karthikeyan, Ramanujam Marimuthu, Ganapathy Ramasubramanian, Chellamuthu Arunachal, Gautham BaHammam, Ahmed S Spence, David Warren Cardinali, Daniel P Brown, Gregory M Pandi-Perumal, Seithikurippu R Neuropsychiatr Dis Treat Original Research BACKGROUND: Sleep–wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08–2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ(2)=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. CONCLUSION: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group. Dove Medical Press 2014-12-09 /pmc/articles/PMC4267513/ /pubmed/25525361 http://dx.doi.org/10.2147/NDT.S73765 Text en © 2014 Karthikeyan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Karthikeyan, Ramanujam
Marimuthu, Ganapathy
Ramasubramanian, Chellamuthu
Arunachal, Gautham
BaHammam, Ahmed S
Spence, David Warren
Cardinali, Daniel P
Brown, Gregory M
Pandi-Perumal, Seithikurippu R
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title_full Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title_fullStr Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title_full_unstemmed Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title_short Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title_sort association of per3 length polymorphism with bipolar i disorder and schizophrenia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267513/
https://www.ncbi.nlm.nih.gov/pubmed/25525361
http://dx.doi.org/10.2147/NDT.S73765
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