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Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
BACKGROUND: Sleep–wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267513/ https://www.ncbi.nlm.nih.gov/pubmed/25525361 http://dx.doi.org/10.2147/NDT.S73765 |
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author | Karthikeyan, Ramanujam Marimuthu, Ganapathy Ramasubramanian, Chellamuthu Arunachal, Gautham BaHammam, Ahmed S Spence, David Warren Cardinali, Daniel P Brown, Gregory M Pandi-Perumal, Seithikurippu R |
author_facet | Karthikeyan, Ramanujam Marimuthu, Ganapathy Ramasubramanian, Chellamuthu Arunachal, Gautham BaHammam, Ahmed S Spence, David Warren Cardinali, Daniel P Brown, Gregory M Pandi-Perumal, Seithikurippu R |
author_sort | Karthikeyan, Ramanujam |
collection | PubMed |
description | BACKGROUND: Sleep–wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08–2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ(2)=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. CONCLUSION: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group. |
format | Online Article Text |
id | pubmed-4267513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-42675132014-12-18 Association of Per3 length polymorphism with bipolar I disorder and schizophrenia Karthikeyan, Ramanujam Marimuthu, Ganapathy Ramasubramanian, Chellamuthu Arunachal, Gautham BaHammam, Ahmed S Spence, David Warren Cardinali, Daniel P Brown, Gregory M Pandi-Perumal, Seithikurippu R Neuropsychiatr Dis Treat Original Research BACKGROUND: Sleep–wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08–2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ(2)=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. CONCLUSION: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group. Dove Medical Press 2014-12-09 /pmc/articles/PMC4267513/ /pubmed/25525361 http://dx.doi.org/10.2147/NDT.S73765 Text en © 2014 Karthikeyan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Karthikeyan, Ramanujam Marimuthu, Ganapathy Ramasubramanian, Chellamuthu Arunachal, Gautham BaHammam, Ahmed S Spence, David Warren Cardinali, Daniel P Brown, Gregory M Pandi-Perumal, Seithikurippu R Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title | Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title_full | Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title_fullStr | Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title_full_unstemmed | Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title_short | Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title_sort | association of per3 length polymorphism with bipolar i disorder and schizophrenia |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267513/ https://www.ncbi.nlm.nih.gov/pubmed/25525361 http://dx.doi.org/10.2147/NDT.S73765 |
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