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Transcriptional bypass of regioisomeric ethylated thymidine lesions by T7 RNA polymerase and human RNA polymerase II

Alkylative damage to DNA can be induced by environmental chemicals, endogenous metabolites and some commonly prescribed chemotherapeutic agents. The regioisomeric N3-, O(2)- and O(4)-ethylthymidine (N3-, O(2)- and O(4)-EtdT, respectively) represent an important class of ethylated DNA lesions. Using...

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Detalles Bibliográficos
Autores principales:	You, Changjun, Wang, Pengcheng, Dai, Xiaoxia, Wang, Yinsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267633/ https://www.ncbi.nlm.nih.gov/pubmed/25404131 http://dx.doi.org/10.1093/nar/gku1183

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