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The Mtr4 ratchet helix and arch domain both function to promote RNA unwinding
Mtr4 is a conserved Ski2-like RNA helicase and a subunit of the TRAMP complex that activates exosome-mediated 3′-5′ turnover in nuclear RNA surveillance and processing pathways. Prominent features of the Mtr4 structure include a four-domain ring-like helicase core and a large arch domain that spans...
Autores principales: | Taylor, Lacy L., Jackson, Ryan N., Rexhepaj, Megi, King, Alejandra Klauer, Lott, Lindsey K., van Hoof, Ambro, Johnson, Sean J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267639/ https://www.ncbi.nlm.nih.gov/pubmed/25414331 http://dx.doi.org/10.1093/nar/gku1208 |
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