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Structural basis for inhibition of DNA replication by aphidicolin

Natural tetracyclic diterpenoid aphidicolin is a potent and specific inhibitor of B-family DNA polymerases, haltering replication and possessing a strong antimitotic activity in human cancer cell lines. Clinical trials revealed limitations of aphidicolin as an antitumor drug because of its low solub...

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Detalles Bibliográficos
Autores principales:	Baranovskiy, Andrey G., Babayeva, Nigar D., Suwa, Yoshiaki, Gu, Jianyou, Pavlov, Youri I., Tahirov, Tahir H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267640/ https://www.ncbi.nlm.nih.gov/pubmed/25429975 http://dx.doi.org/10.1093/nar/gku1209

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