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The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells

In the liver Wnt-signaling contributes to the metabolic fate of hepatocytes, but the precise role of the TCF7L2 in this process is unknown. We employed a temporal RNA-Seq approach to examine gene expression 3–96 h following Tcf7l2 silencing in rat hepatoma cells, and combined this with ChIP-Seq to i...

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Detalles Bibliográficos
Autores principales:	Norton, Luke, Chen, Xi, Fourcaudot, Marcel, Acharya, Nikhil K., DeFronzo, Ralph A., Heikkinen, Sami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267646/ https://www.ncbi.nlm.nih.gov/pubmed/25414334 http://dx.doi.org/10.1093/nar/gku1225

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