Multimeric Scaffolds Displaying the HIV-1 Envelope MPER Induce MPER-Specific Antibodies and Cross-Neutralizing Antibodies when Co-Immunized with gp160 DNA

Developing a vaccine that overcomes the diversity of HIV-1 is likely to require a strategy that directs antibody (Ab) responses toward conserved regions of the viral Envelope (Env). However, the generation of neutralizing Abs (NAbs) targeting these regions through vaccination has proven to be diffic...

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Detalles Bibliográficos
Autores principales: Krebs, Shelly J., McBurney, Sean P., Kovarik, Dina N., Waddell, Chelsea D., Jaworski, J. Pablo, Sutton, William F., Gomes, Michelle M., Trovato, Maria, Waagmeester, Garret, Barnett, Susan J., DeBerardinis, Piergiuseppe, Haigwood, Nancy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267727/
https://www.ncbi.nlm.nih.gov/pubmed/25514675
http://dx.doi.org/10.1371/journal.pone.0113463

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