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PlGF mediates neutrophil elastase-induced airway epithelial cell apoptosis and emphysema
BACKGROUND: Chronic pulmonary obstructive disease (COPD) has become the fourth leading cause of death worldwide. Cigarette smoking induces neutrophil elastase (NE) and contributes to COPD, but the detailed mechanisms involved are not fully established. In an animal model of pulmonary emphysema, ther...
Autores principales: | Hou, Hsin-Han, Cheng, Shih-Lung, Chung, Kuei-Pin, Wei, Shu-Chen, Tsao, Po-Nien, Lu, Hsuan-Hsuan, Wang, Hao-Chien, Yu, Chong-Jen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267747/ https://www.ncbi.nlm.nih.gov/pubmed/25186164 http://dx.doi.org/10.1186/s12931-014-0106-1 |
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