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Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report
OBJECTIVE: To describe a case of leucine-rich glioma-inactivated protein 1 (LGI1) antibody–associated encephalitis. METHODS: The clinical and ancillary data and brain MRIs were gathered retrospectively by chart review. Relevant literature on similar cases was also reviewed. RESULTS: The diagnosis of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268038/ https://www.ncbi.nlm.nih.gov/pubmed/25520958 http://dx.doi.org/10.1212/NXI.0000000000000051 |
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author | Mayasi, Yunis Takhtani, Deepak Garg, Neeta |
author_facet | Mayasi, Yunis Takhtani, Deepak Garg, Neeta |
author_sort | Mayasi, Yunis |
collection | PubMed |
description | OBJECTIVE: To describe a case of leucine-rich glioma-inactivated protein 1 (LGI1) antibody–associated encephalitis. METHODS: The clinical and ancillary data and brain MRIs were gathered retrospectively by chart review. Relevant literature on similar cases was also reviewed. RESULTS: The diagnosis of LGI1 antibody–associated autoimmune encephalitis was based on the typical clinical presentation of seizures, psychiatric symptoms, and memory loss as well as negative diagnostic testing for cancer; the diagnosis was confirmed by positive LGI1 antibody. The patient responded favorably to treatment with IV immunoglobulin and continues to do well. CONCLUSION: LGI1 antibody–associated encephalitis has increasingly been recognized as a primary autoimmune disorder with good prognosis and response to treatment. |
format | Online Article Text |
id | pubmed-4268038 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-42680382014-12-17 Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report Mayasi, Yunis Takhtani, Deepak Garg, Neeta Neurol Neuroimmunol Neuroinflamm Article OBJECTIVE: To describe a case of leucine-rich glioma-inactivated protein 1 (LGI1) antibody–associated encephalitis. METHODS: The clinical and ancillary data and brain MRIs were gathered retrospectively by chart review. Relevant literature on similar cases was also reviewed. RESULTS: The diagnosis of LGI1 antibody–associated autoimmune encephalitis was based on the typical clinical presentation of seizures, psychiatric symptoms, and memory loss as well as negative diagnostic testing for cancer; the diagnosis was confirmed by positive LGI1 antibody. The patient responded favorably to treatment with IV immunoglobulin and continues to do well. CONCLUSION: LGI1 antibody–associated encephalitis has increasingly been recognized as a primary autoimmune disorder with good prognosis and response to treatment. Lippincott Williams & Wilkins 2014-12-11 /pmc/articles/PMC4268038/ /pubmed/25520958 http://dx.doi.org/10.1212/NXI.0000000000000051 Text en © 2014 American Academy of Neurology This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative 3.0 License, which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially. |
spellingShingle | Article Mayasi, Yunis Takhtani, Deepak Garg, Neeta Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report |
title | Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report |
title_full | Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report |
title_fullStr | Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report |
title_full_unstemmed | Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report |
title_short | Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report |
title_sort | leucine-rich glioma-inactivated protein 1 antibody encephalitis: a case report |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268038/ https://www.ncbi.nlm.nih.gov/pubmed/25520958 http://dx.doi.org/10.1212/NXI.0000000000000051 |
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