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Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report

OBJECTIVE: To describe a case of leucine-rich glioma-inactivated protein 1 (LGI1) antibody–associated encephalitis. METHODS: The clinical and ancillary data and brain MRIs were gathered retrospectively by chart review. Relevant literature on similar cases was also reviewed. RESULTS: The diagnosis of...

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Detalles Bibliográficos
Autores principales: Mayasi, Yunis, Takhtani, Deepak, Garg, Neeta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268038/
https://www.ncbi.nlm.nih.gov/pubmed/25520958
http://dx.doi.org/10.1212/NXI.0000000000000051
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author Mayasi, Yunis
Takhtani, Deepak
Garg, Neeta
author_facet Mayasi, Yunis
Takhtani, Deepak
Garg, Neeta
author_sort Mayasi, Yunis
collection PubMed
description OBJECTIVE: To describe a case of leucine-rich glioma-inactivated protein 1 (LGI1) antibody–associated encephalitis. METHODS: The clinical and ancillary data and brain MRIs were gathered retrospectively by chart review. Relevant literature on similar cases was also reviewed. RESULTS: The diagnosis of LGI1 antibody–associated autoimmune encephalitis was based on the typical clinical presentation of seizures, psychiatric symptoms, and memory loss as well as negative diagnostic testing for cancer; the diagnosis was confirmed by positive LGI1 antibody. The patient responded favorably to treatment with IV immunoglobulin and continues to do well. CONCLUSION: LGI1 antibody–associated encephalitis has increasingly been recognized as a primary autoimmune disorder with good prognosis and response to treatment.
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spelling pubmed-42680382014-12-17 Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report Mayasi, Yunis Takhtani, Deepak Garg, Neeta Neurol Neuroimmunol Neuroinflamm Article OBJECTIVE: To describe a case of leucine-rich glioma-inactivated protein 1 (LGI1) antibody–associated encephalitis. METHODS: The clinical and ancillary data and brain MRIs were gathered retrospectively by chart review. Relevant literature on similar cases was also reviewed. RESULTS: The diagnosis of LGI1 antibody–associated autoimmune encephalitis was based on the typical clinical presentation of seizures, psychiatric symptoms, and memory loss as well as negative diagnostic testing for cancer; the diagnosis was confirmed by positive LGI1 antibody. The patient responded favorably to treatment with IV immunoglobulin and continues to do well. CONCLUSION: LGI1 antibody–associated encephalitis has increasingly been recognized as a primary autoimmune disorder with good prognosis and response to treatment. Lippincott Williams & Wilkins 2014-12-11 /pmc/articles/PMC4268038/ /pubmed/25520958 http://dx.doi.org/10.1212/NXI.0000000000000051 Text en © 2014 American Academy of Neurology This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative 3.0 License, which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Article
Mayasi, Yunis
Takhtani, Deepak
Garg, Neeta
Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report
title Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report
title_full Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report
title_fullStr Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report
title_full_unstemmed Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report
title_short Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report
title_sort leucine-rich glioma-inactivated protein 1 antibody encephalitis: a case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268038/
https://www.ncbi.nlm.nih.gov/pubmed/25520958
http://dx.doi.org/10.1212/NXI.0000000000000051
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