Impaired epithelial Na(+) channels activity contributes to cystogenesis and development of autosomal recessive polycystic kidney disease in PCK rats

BACKGROUND: Autosomal recessive polycystic kidney disease (ARPKD) is a genetic disorder characterized by the development of renal cysts of the tubular epithelial cell origin. Epithelial Na(+) channel (ENaC) is responsible for sodium reabsorption in the aldosterone-sensitive distal nephron. Here we i...

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Detalles Bibliográficos
Autores principales: Pavlov, Tengis S., Levchenko, Vladislav, Ilatovskaya, Daria V., Palygin, Oleg, Staruschenko, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268054/
https://www.ncbi.nlm.nih.gov/pubmed/25279988
http://dx.doi.org/10.1038/pr.2014.145

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