Circadian rhythm of plasma and urinary angiotensinogen in healthy volunteers and in patients with chronic kidney disease

The urinary angiotensinogen (AGT) excretion rate could be a novel biomarker for the intrarenal activity of the reninangiotensin system. Little is known about the circadian rhythm of AGT levels in plasma or urine. In this short article, making use of data in plasma and urine of healthy volunteers and...

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Autores principales: Nishijima, Yoko, Kobori, Hiroyuki, Kaifu, Kumiko, Mizushige, Tomoko, Hara, Taiga, Nishiyama, Akira, Kohno, Masakazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268126/
https://www.ncbi.nlm.nih.gov/pubmed/25381307
http://dx.doi.org/10.1177/1470320314557584
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author Nishijima, Yoko
Kobori, Hiroyuki
Kaifu, Kumiko
Mizushige, Tomoko
Hara, Taiga
Nishiyama, Akira
Kohno, Masakazu
author_facet Nishijima, Yoko
Kobori, Hiroyuki
Kaifu, Kumiko
Mizushige, Tomoko
Hara, Taiga
Nishiyama, Akira
Kohno, Masakazu
author_sort Nishijima, Yoko
collection PubMed
description The urinary angiotensinogen (AGT) excretion rate could be a novel biomarker for the intrarenal activity of the reninangiotensin system. Little is known about the circadian rhythm of AGT levels in plasma or urine. In this short article, making use of data in plasma and urine of healthy volunteers and patients with chronic kidney diseases, we first report that we were unable to find evidence for a circadian rhythm of AGT under any condition. Next we critically discuss to what degree elevated urinary AGT levels might be considered an independent biomarker that is not simply the non-specific consequence of proteinuria.
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spelling pubmed-42681262014-12-17 Circadian rhythm of plasma and urinary angiotensinogen in healthy volunteers and in patients with chronic kidney disease Nishijima, Yoko Kobori, Hiroyuki Kaifu, Kumiko Mizushige, Tomoko Hara, Taiga Nishiyama, Akira Kohno, Masakazu J Renin Angiotensin Aldosterone Syst Article The urinary angiotensinogen (AGT) excretion rate could be a novel biomarker for the intrarenal activity of the reninangiotensin system. Little is known about the circadian rhythm of AGT levels in plasma or urine. In this short article, making use of data in plasma and urine of healthy volunteers and patients with chronic kidney diseases, we first report that we were unable to find evidence for a circadian rhythm of AGT under any condition. Next we critically discuss to what degree elevated urinary AGT levels might be considered an independent biomarker that is not simply the non-specific consequence of proteinuria. 2014-11-07 2014-12 /pmc/articles/PMC4268126/ /pubmed/25381307 http://dx.doi.org/10.1177/1470320314557584 Text en Creative Commons CC-BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).
spellingShingle Article
Nishijima, Yoko
Kobori, Hiroyuki
Kaifu, Kumiko
Mizushige, Tomoko
Hara, Taiga
Nishiyama, Akira
Kohno, Masakazu
Circadian rhythm of plasma and urinary angiotensinogen in healthy volunteers and in patients with chronic kidney disease
title Circadian rhythm of plasma and urinary angiotensinogen in healthy volunteers and in patients with chronic kidney disease
title_full Circadian rhythm of plasma and urinary angiotensinogen in healthy volunteers and in patients with chronic kidney disease
title_fullStr Circadian rhythm of plasma and urinary angiotensinogen in healthy volunteers and in patients with chronic kidney disease
title_full_unstemmed Circadian rhythm of plasma and urinary angiotensinogen in healthy volunteers and in patients with chronic kidney disease
title_short Circadian rhythm of plasma and urinary angiotensinogen in healthy volunteers and in patients with chronic kidney disease
title_sort circadian rhythm of plasma and urinary angiotensinogen in healthy volunteers and in patients with chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268126/
https://www.ncbi.nlm.nih.gov/pubmed/25381307
http://dx.doi.org/10.1177/1470320314557584
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