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Hypertonic saline solution reduces the oxidative stress responses in traumatic brain injury patients

BACKGROUND: Oxidative stress processes play an important role in the pathogenesis of secondary brain injury after traumatic brain injury (TBI). Hypertonic saline (HTS) has advantages as being preferred osmotic agent, but few studies investigated oxidant and antioxidant effects of HTS in TBI. This st...

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Autores principales: Mojtahedzadeh, Mojtaba, Ahmadi, Arezoo, Mahmoodpoor, Ata, Beigmohammadi, Mohammad Taghi, Abdollahi, Mohammad, Khazaeipour, Zahra, Shaki, Fatemeh, Kuochaki, Bizhan, Hendouei, Narjes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268196/
https://www.ncbi.nlm.nih.gov/pubmed/25535502
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author Mojtahedzadeh, Mojtaba
Ahmadi, Arezoo
Mahmoodpoor, Ata
Beigmohammadi, Mohammad Taghi
Abdollahi, Mohammad
Khazaeipour, Zahra
Shaki, Fatemeh
Kuochaki, Bizhan
Hendouei, Narjes
author_facet Mojtahedzadeh, Mojtaba
Ahmadi, Arezoo
Mahmoodpoor, Ata
Beigmohammadi, Mohammad Taghi
Abdollahi, Mohammad
Khazaeipour, Zahra
Shaki, Fatemeh
Kuochaki, Bizhan
Hendouei, Narjes
author_sort Mojtahedzadeh, Mojtaba
collection PubMed
description BACKGROUND: Oxidative stress processes play an important role in the pathogenesis of secondary brain injury after traumatic brain injury (TBI). Hypertonic saline (HTS) has advantages as being preferred osmotic agent, but few studies investigated oxidant and antioxidant effects of HTS in TBI. This study was designed to compare two different regimens of HTS 5% with mannitol on TBI-induced oxidative stress. MATERIALS AND METHODS: Thirty-three adult patients with TBI were recruited and have randomly received one of the three protocols: 125 cc of HTS 5% every 6 h as bolus, 500 cc of HTS 5%as infusion for 24 h or 1 g/kg mannitol of 20% as a bolus, repeated with a dose of 0.25-0.5 g/kg every 6 h based on patient's response for 3 days. Serum total antioxidant power (TAP), reactive oxygen species (ROS) and nitric oxide (NO) were measured at baseline and daily for 3 days. RESULTS: Initial serum ROS and NO levels in patients were higher than control(6.86± [3.2] vs. 1.57± [0.5] picoM, P = 0.001, 14.6± [1.6] vs. 7.8± [3.9] mM, P = 0.001, respectively). Levels of ROS have decreased for all patients, but reduction was significantly after HTS infusion and mannitol (3. 08 [±3.1] to 1.07 [±1.6], P = 0.001, 5.6 [±3.4] to 2.5 [±1.8], P = 0.003 respectively). During study, NO levels significantly decreased in HTS infusion but significantly increased in mannitol. TAP Levels had decreased in all patients during study especially in mannitol (P = 0.004). CONCLUSION: Hypertonic saline 5% has significant effects on the oxidant responses compared to mannitol following TBI that makes HTS as a perfect therapeutic intervention for reducing unfavorable outcomes in TBI patients.
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spelling pubmed-42681962014-12-22 Hypertonic saline solution reduces the oxidative stress responses in traumatic brain injury patients Mojtahedzadeh, Mojtaba Ahmadi, Arezoo Mahmoodpoor, Ata Beigmohammadi, Mohammad Taghi Abdollahi, Mohammad Khazaeipour, Zahra Shaki, Fatemeh Kuochaki, Bizhan Hendouei, Narjes J Res Med Sci Original Article BACKGROUND: Oxidative stress processes play an important role in the pathogenesis of secondary brain injury after traumatic brain injury (TBI). Hypertonic saline (HTS) has advantages as being preferred osmotic agent, but few studies investigated oxidant and antioxidant effects of HTS in TBI. This study was designed to compare two different regimens of HTS 5% with mannitol on TBI-induced oxidative stress. MATERIALS AND METHODS: Thirty-three adult patients with TBI were recruited and have randomly received one of the three protocols: 125 cc of HTS 5% every 6 h as bolus, 500 cc of HTS 5%as infusion for 24 h or 1 g/kg mannitol of 20% as a bolus, repeated with a dose of 0.25-0.5 g/kg every 6 h based on patient's response for 3 days. Serum total antioxidant power (TAP), reactive oxygen species (ROS) and nitric oxide (NO) were measured at baseline and daily for 3 days. RESULTS: Initial serum ROS and NO levels in patients were higher than control(6.86± [3.2] vs. 1.57± [0.5] picoM, P = 0.001, 14.6± [1.6] vs. 7.8± [3.9] mM, P = 0.001, respectively). Levels of ROS have decreased for all patients, but reduction was significantly after HTS infusion and mannitol (3. 08 [±3.1] to 1.07 [±1.6], P = 0.001, 5.6 [±3.4] to 2.5 [±1.8], P = 0.003 respectively). During study, NO levels significantly decreased in HTS infusion but significantly increased in mannitol. TAP Levels had decreased in all patients during study especially in mannitol (P = 0.004). CONCLUSION: Hypertonic saline 5% has significant effects on the oxidant responses compared to mannitol following TBI that makes HTS as a perfect therapeutic intervention for reducing unfavorable outcomes in TBI patients. Medknow Publications & Media Pvt Ltd 2014-09 /pmc/articles/PMC4268196/ /pubmed/25535502 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mojtahedzadeh, Mojtaba
Ahmadi, Arezoo
Mahmoodpoor, Ata
Beigmohammadi, Mohammad Taghi
Abdollahi, Mohammad
Khazaeipour, Zahra
Shaki, Fatemeh
Kuochaki, Bizhan
Hendouei, Narjes
Hypertonic saline solution reduces the oxidative stress responses in traumatic brain injury patients
title Hypertonic saline solution reduces the oxidative stress responses in traumatic brain injury patients
title_full Hypertonic saline solution reduces the oxidative stress responses in traumatic brain injury patients
title_fullStr Hypertonic saline solution reduces the oxidative stress responses in traumatic brain injury patients
title_full_unstemmed Hypertonic saline solution reduces the oxidative stress responses in traumatic brain injury patients
title_short Hypertonic saline solution reduces the oxidative stress responses in traumatic brain injury patients
title_sort hypertonic saline solution reduces the oxidative stress responses in traumatic brain injury patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268196/
https://www.ncbi.nlm.nih.gov/pubmed/25535502
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