A genome-wide association study of Hodgkin Lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21, and 10p14 (GATA3)

To identify predisposition loci for classical Hodgkin Lymphoma (cHL) we conducted a genome-wide association study of 589 cHL cases and 5,199 controls with validation in 4 independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, RE...

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Detalles Bibliográficos
Autores principales: Enciso-Mora, Victor, Broderick, Peter, Ma, Yussanne, Jarrett, Ruth F, Hjalgrim, Henrik, Hemminki, Kari, van den Berg, Anke, Olver, Bianca, Lloyd, Amy, Dobbins, Sara E, Lightfoot, Tracy, van Leeuwen, Flora E, Försti, Asta, Diepstra, Arjan, Broeks, Annegien, Vijayakrishnan, Jayaram, Shield, Lesley, Lake, Annette, Montgomery, Dorothy, Roman, Eve, Engert, Andreas, von Strandmann, Elke Pogge, Reiners, Katrin S., Nolte, Ilja M, Smedby, Karin E, Adami, Hans-Olov, Russell, Nicola S, Glimelius, Bengt, Hamilton-Dutoit, Stephen, de Bruin, Marieke, Ryder, Lars P, Molin, Daniel, Sorensen, Karina Meden, Chang, Ellen T, Taylor, Malcolm, Cooke, Rosie, Hofstra, Robert, Westers, Helga, van Wezel, Tom, van Eijk, Ronald, Ashworth, Alan, Rostgaard, Klaus, Melbye, Mads, Swerdlow, Anthony J, Houlston, Richard S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268499/
https://www.ncbi.nlm.nih.gov/pubmed/21037568
http://dx.doi.org/10.1038/ng.696
Descripción
Sumario:To identify predisposition loci for classical Hodgkin Lymphoma (cHL) we conducted a genome-wide association study of 589 cHL cases and 5,199 controls with validation in 4 independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL; odds ratio [OR]=1.22, P(combined)=1.91×10(−8)), 8q24.21 (rs2019960, PVT1; OR=1.33, P(combined)=1.26×10(−13)) and 10p14 (rs501764, GATA3; OR=1.25, P(combined)=7.05×10(−8)). Furthermore, we confirmed the role of the MHC in disease etiology by revealing a strong HLA association (rs6903608; OR=1.70, P(combined)=2.84×10(−50)). These data provide new insight into the pathogenesis of cHL.

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