Cargando…

Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice

BACKGROUND: Korean ginseng is a well-known medicinal herb that has been widely used in traditional medicine to treat various diseases, including asthma. Ginseng can be classified as white ginseng (WG) or red ginseng (RG), according to processing conditions. In this study, the authors compared the ef...

Descripción completa

Detalles Bibliográficos
Autores principales: Lim, Chi-Yeon, Moon, Jeong-Min, Kim, Bu-Yeo, Lim, Se-Hyun, Lee, Guem-San, Yu, Hak-Sun, Cho, Su-In
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268570/
https://www.ncbi.nlm.nih.gov/pubmed/25535475
http://dx.doi.org/10.1016/j.jgr.2014.07.004
_version_ 1782349254456508416
author Lim, Chi-Yeon
Moon, Jeong-Min
Kim, Bu-Yeo
Lim, Se-Hyun
Lee, Guem-San
Yu, Hak-Sun
Cho, Su-In
author_facet Lim, Chi-Yeon
Moon, Jeong-Min
Kim, Bu-Yeo
Lim, Se-Hyun
Lee, Guem-San
Yu, Hak-Sun
Cho, Su-In
author_sort Lim, Chi-Yeon
collection PubMed
description BACKGROUND: Korean ginseng is a well-known medicinal herb that has been widely used in traditional medicine to treat various diseases, including asthma. Ginseng can be classified as white ginseng (WG) or red ginseng (RG), according to processing conditions. In this study, the authors compared the efficacies of these two ginseng types in a mouse model of acute asthma. METHODS: To produce the acute asthma model, BALB/c mice were sensitized with ovalbumin (OVA) and aluminum hydroxide, and then challenged with OVA. WG and RG extracts were administered to mice orally. The influences of WG and RG on airway hyperresponsiveness (AHR), immune cell distributions in bronchoalveolar lavage fluid (BALF), and OVA-specific immunoglobulin E (IgE), IgG1, and IgG2a in serum were investigated. Cytokine production by lymphocytes isolated from peribronchial lymph nodes and histopathological changes was also examined. RESULTS: In OVA-sensitized mice, both WG and RG reduced AHR and suppressed immune cell infiltration in bronchoalveolar regions. BALF OVA-specific IgE levels were significantly lower in RG-treated OVA-sensitized mice than in the OVA-sensitized control group. WG and RG also suppressed inflammatory cytokine production by peribronchial lymphocytes. Histopathological findings showed reduced inflammatory cell infiltration and airway remodeling (e.g., epithelial hyperplasia) in WG- and RG-treated OVA mice compared with OVA controls. CONCLUSION: In this study, WG and RG showed antiasthmatic effects in an OVA-sensitized mouse model, and the efficacies of RG were found to be better than those of WG.
format Online
Article
Text
id pubmed-4268570
institution National Center for Biotechnology Information
language English
publishDate 2014
record_format MEDLINE/PubMed
spelling pubmed-42685702014-12-22 Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice Lim, Chi-Yeon Moon, Jeong-Min Kim, Bu-Yeo Lim, Se-Hyun Lee, Guem-San Yu, Hak-Sun Cho, Su-In J Ginseng Res Research Article BACKGROUND: Korean ginseng is a well-known medicinal herb that has been widely used in traditional medicine to treat various diseases, including asthma. Ginseng can be classified as white ginseng (WG) or red ginseng (RG), according to processing conditions. In this study, the authors compared the efficacies of these two ginseng types in a mouse model of acute asthma. METHODS: To produce the acute asthma model, BALB/c mice were sensitized with ovalbumin (OVA) and aluminum hydroxide, and then challenged with OVA. WG and RG extracts were administered to mice orally. The influences of WG and RG on airway hyperresponsiveness (AHR), immune cell distributions in bronchoalveolar lavage fluid (BALF), and OVA-specific immunoglobulin E (IgE), IgG1, and IgG2a in serum were investigated. Cytokine production by lymphocytes isolated from peribronchial lymph nodes and histopathological changes was also examined. RESULTS: In OVA-sensitized mice, both WG and RG reduced AHR and suppressed immune cell infiltration in bronchoalveolar regions. BALF OVA-specific IgE levels were significantly lower in RG-treated OVA-sensitized mice than in the OVA-sensitized control group. WG and RG also suppressed inflammatory cytokine production by peribronchial lymphocytes. Histopathological findings showed reduced inflammatory cell infiltration and airway remodeling (e.g., epithelial hyperplasia) in WG- and RG-treated OVA mice compared with OVA controls. CONCLUSION: In this study, WG and RG showed antiasthmatic effects in an OVA-sensitized mouse model, and the efficacies of RG were found to be better than those of WG. 2014-08-01 2015-01 /pmc/articles/PMC4268570/ /pubmed/25535475 http://dx.doi.org/10.1016/j.jgr.2014.07.004 Text en © 2015 The Korean Society of Ginseng. Published by Elsevier B.V. All rights reserved. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the CC-BY-NC License (http://creativecommons.org/licenses/by-nc/3.0).
spellingShingle Research Article
Lim, Chi-Yeon
Moon, Jeong-Min
Kim, Bu-Yeo
Lim, Se-Hyun
Lee, Guem-San
Yu, Hak-Sun
Cho, Su-In
Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice
title Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice
title_full Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice
title_fullStr Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice
title_full_unstemmed Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice
title_short Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice
title_sort comparative study of korean white ginseng and korean red ginseng on efficacies of ova-induced asthma model in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268570/
https://www.ncbi.nlm.nih.gov/pubmed/25535475
http://dx.doi.org/10.1016/j.jgr.2014.07.004
work_keys_str_mv AT limchiyeon comparativestudyofkoreanwhiteginsengandkoreanredginsengonefficaciesofovainducedasthmamodelinmice
AT moonjeongmin comparativestudyofkoreanwhiteginsengandkoreanredginsengonefficaciesofovainducedasthmamodelinmice
AT kimbuyeo comparativestudyofkoreanwhiteginsengandkoreanredginsengonefficaciesofovainducedasthmamodelinmice
AT limsehyun comparativestudyofkoreanwhiteginsengandkoreanredginsengonefficaciesofovainducedasthmamodelinmice
AT leeguemsan comparativestudyofkoreanwhiteginsengandkoreanredginsengonefficaciesofovainducedasthmamodelinmice
AT yuhaksun comparativestudyofkoreanwhiteginsengandkoreanredginsengonefficaciesofovainducedasthmamodelinmice
AT chosuin comparativestudyofkoreanwhiteginsengandkoreanredginsengonefficaciesofovainducedasthmamodelinmice