Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity

Angiogenesis plays an important role in cancer and ophthalmic disorders such as age-related macular degeneration and diabetic retinopathy. The vascular endothelial growth factor (VEGF) family and corresponding receptors are regulators of angiogenesis and have been much investigated as therapeutic ta...

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Detalles Bibliográficos
Autores principales: Fleetwood, Filippa, Klint, Susanne, Hanze, Martin, Gunneriusson, Elin, Frejd, Fredrik Y., Ståhl, Stefan, Löfblom, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268634/
https://www.ncbi.nlm.nih.gov/pubmed/25515662
http://dx.doi.org/10.1038/srep07518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268634/
https://www.ncbi.nlm.nih.gov/pubmed/25515662
http://dx.doi.org/10.1038/srep07518

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