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Direct muscle neurotization after end-to end and end-to-side neurorrhaphy: An experimental study in the rat forelimb model
The need for the continuous research of new tools for improving motor function recovery after nerve injury is justified by the still often unsatisfactory clinical outcome in these patients. It has been previously shown that the combined use of two reconstructive techniques, namely end-to-side neuror...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268728/ https://www.ncbi.nlm.nih.gov/pubmed/25538749 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.29.005 |
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author | Papalia, Igor Ronchi, Giulia Muratori, Luisa Mazzucco, Alessandra Magaudda, Ludovico Geuna, Stefano |
author_facet | Papalia, Igor Ronchi, Giulia Muratori, Luisa Mazzucco, Alessandra Magaudda, Ludovico Geuna, Stefano |
author_sort | Papalia, Igor |
collection | PubMed |
description | The need for the continuous research of new tools for improving motor function recovery after nerve injury is justified by the still often unsatisfactory clinical outcome in these patients. It has been previously shown that the combined use of two reconstructive techniques, namely end-to-side neurorrhaphy and direct muscle neurotization in the rat hindlimb model, can lead to good results in terms of skeletal muscle reinnervation. Here we show that, in the rat forelimb model, the combined use of direct muscle neurotization with either end-to-end or end-to-side neurorrhaphy to reinnervate the denervated flexor digitorum muscles, leads to muscle atrophy prevention over a long postoperative time lapse (10 months). By contrast, very little motor recovery (in case of end-to-end neurorrhaphy) and almost no motor recovery (in case of end-to-side neurorrhaphy) were observed in the grasping activity controlled by flexor digitorum muscles. It can thus be concluded that, at least in the rat, direct muscle neurotization after both end-to-end and end-to-side neurorrhaphy represents a good strategy for preventing denervation-related muscle atrophy but not for regaining the lost motor function. |
format | Online Article Text |
id | pubmed-4268728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42687282014-12-23 Direct muscle neurotization after end-to end and end-to-side neurorrhaphy: An experimental study in the rat forelimb model Papalia, Igor Ronchi, Giulia Muratori, Luisa Mazzucco, Alessandra Magaudda, Ludovico Geuna, Stefano Neural Regen Res Special Issue The need for the continuous research of new tools for improving motor function recovery after nerve injury is justified by the still often unsatisfactory clinical outcome in these patients. It has been previously shown that the combined use of two reconstructive techniques, namely end-to-side neurorrhaphy and direct muscle neurotization in the rat hindlimb model, can lead to good results in terms of skeletal muscle reinnervation. Here we show that, in the rat forelimb model, the combined use of direct muscle neurotization with either end-to-end or end-to-side neurorrhaphy to reinnervate the denervated flexor digitorum muscles, leads to muscle atrophy prevention over a long postoperative time lapse (10 months). By contrast, very little motor recovery (in case of end-to-end neurorrhaphy) and almost no motor recovery (in case of end-to-side neurorrhaphy) were observed in the grasping activity controlled by flexor digitorum muscles. It can thus be concluded that, at least in the rat, direct muscle neurotization after both end-to-end and end-to-side neurorrhaphy represents a good strategy for preventing denervation-related muscle atrophy but not for regaining the lost motor function. Medknow Publications & Media Pvt Ltd 2012-10-15 /pmc/articles/PMC4268728/ /pubmed/25538749 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.29.005 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Special Issue Papalia, Igor Ronchi, Giulia Muratori, Luisa Mazzucco, Alessandra Magaudda, Ludovico Geuna, Stefano Direct muscle neurotization after end-to end and end-to-side neurorrhaphy: An experimental study in the rat forelimb model |
title | Direct muscle neurotization after end-to end and end-to-side neurorrhaphy: An experimental study in the rat forelimb model |
title_full | Direct muscle neurotization after end-to end and end-to-side neurorrhaphy: An experimental study in the rat forelimb model |
title_fullStr | Direct muscle neurotization after end-to end and end-to-side neurorrhaphy: An experimental study in the rat forelimb model |
title_full_unstemmed | Direct muscle neurotization after end-to end and end-to-side neurorrhaphy: An experimental study in the rat forelimb model |
title_short | Direct muscle neurotization after end-to end and end-to-side neurorrhaphy: An experimental study in the rat forelimb model |
title_sort | direct muscle neurotization after end-to end and end-to-side neurorrhaphy: an experimental study in the rat forelimb model |
topic | Special Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268728/ https://www.ncbi.nlm.nih.gov/pubmed/25538749 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.29.005 |
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