Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis

Recent evidence suggests that reactive oxygen species (ROS) produced by inflammatory cells drive axonal degeneration in active multiple sclerosis (MS) lesions by inducing mitochondrial dysfunction. Mitochondria are endowed with a variety of antioxidant enzymes, including peroxiredoxin-3 and thioredo...

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Detalles Bibliográficos
Autores principales: Nijland, Philip G, Witte, Maarten E, van het Hof, Bert, van der Pol, Susanne, Bauer, Jan, Lassmann, Hans, van der Valk, Paul, de Vries, Helga E, van Horssen, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268800/
https://www.ncbi.nlm.nih.gov/pubmed/25492529
http://dx.doi.org/10.1186/s40478-014-0170-2

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