Cargando…

Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS

Regulatory T cells are crucial in controlling various functions of effector T cells during experimental autoimmune encephalomyelitis. While regulatory T cells are reported to exert their immunomodulatory effects in the peripheral immune organs, their role within the central nervous system (CNS) duri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koutrolos, Michail, Berer, Kerstin, Kawakami, Naoto, Wekerle, Hartmut, Krishnamoorthy, Gurumoorthy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268825/ https://www.ncbi.nlm.nih.gov/pubmed/25476447 http://dx.doi.org/10.1186/s40478-014-0163-1

Ejemplares similares

Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells
por: Pöllinger, Bernadette, et al.
Publicado: (2009)

Selective Accumulation of Pro-Inflammatory T Cells in the Intestine Contributes to the Resistance to Autoimmune Demyelinating Disease
por: Berer, Kerstin, et al.
Publicado: (2014)

A B cell–driven EAE mouse model reveals the impact of B cell–derived cytokines on CNS autoimmunity
por: Thomann, Anna S., et al.
Publicado: (2023)

Functional and Pathogenic Differences of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis
por: Domingues, Helena S., et al.
Publicado: (2010)

CNS Pericytes Modulate Local T Cell Infiltration in EAE
por: Koch, Kathrin, et al.
Publicado: (2022)

Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion
por: Kawakami, Naoto, et al.
Publicado: (2005)

Neutrophil-related factors as biomarkers in EAE and MS
por: Rumble, Julie M., et al.
Publicado: (2015)

Dietary non-fermentable fiber prevents autoimmune neurological disease by changing gut metabolic and immune status
por: Berer, Kerstin, et al.
Publicado: (2018)

CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model
por: Wang, Ning, et al.
Publicado: (2020)

IL-17A Facilitates Entry of Autoreactive T-Cells and Granulocytes into the CNS During EAE
por: Zimmermann, Julian, et al.
Publicado: (2023)

pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation
por: Duraes, Fernanda V., et al.
Publicado: (2016)

Treg in CNS autoimmune disease
por: Anderton, Stephen M
Publicado: (2012)

Innate Signaling in the CNS Prevents Demyelination in a Focal EAE Model
por: Dubik, Magdalena, et al.
Publicado: (2021)

Appearance of claudin-5(+) leukocyte subtypes in the blood and CNS during progression of EAE
por: Krajewski, Dylan, et al.
Publicado: (2021)

Exosomes with FOXP3 from gene-modified dendritic cells ameliorate the development of EAE by regulating the balance of Th/Treg
por: Jia, Zhen, et al.
Publicado: (2022)

Extended Freeze-Dried BCG Instructed pDCs Induce Suppressive Tregs and Dampen EAE
por: Lippens, Carla, et al.
Publicado: (2018)

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
por: Fransson, Moa, et al.
Publicado: (2012)

Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation
por: Dayton, Jacquelyn R., et al.
Publicado: (2021)

Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin
por: Strauss, Laura, et al.
Publicado: (2009)

The Yin and Yang of Targeting KLRG1(+) Tregs and Effector Cells
por: Borys, Samantha M., et al.
Publicado: (2022)

Induction of Golli-MBP Expression in CNS Macrophages During Acute LPS-Induced CNS Inflammation and Experimental Autoimmune Encephalomyelitis (EAE)
por: Papenfuss, Tracey L., et al.
Publicado: (2007)

Role of Regulatory T Cells (Treg) and the Treg Effector Molecule Fibrinogen-like Protein 2 in Alloimmunity and Autoimmunity
por: Chruscinski, Andrzej, et al.
Publicado: (2015)

Regional CNS responses to IFN-γ determine lesion localization patterns during EAE pathogenesis
por: Lees, Jason R., et al.
Publicado: (2008)

Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production
por: Zorzella-Pezavento, Sofia Fernanda Gonçalves, et al.
Publicado: (2013)

Expression of IL-1β in rhesus EAE and MS lesions is mainly induced in the CNS itself
por: Burm, Saskia Maria, et al.
Publicado: (2016)

Costimulation blockade and Tregs in solid organ transplantation
por: Muckenhuber, Moritz, et al.
Publicado: (2022)

The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg Cells
por: Taylor, Andrew W., et al.
Publicado: (2011)

TRPM2 Cation Channels Modulate T Cell Effector Functions and Contribute to Autoimmune CNS Inflammation
por: Melzer, Nico, et al.
Publicado: (2012)

The Different Functional Distribution of “Not Effector” T Cells (Treg/Tnull) in Colorectal Cancer
por: Niccolai, Elena, et al.
Publicado: (2017)

Knocking at the brain’s door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures
por: Kawakami, Naoto, et al.
Publicado: (2010)

Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients
por: De Matteis, Serena, et al.
Publicado: (2018)

RAM-589.555 favors neuroprotective and anti-inflammatory profile of CNS-resident glial cells in acute relapse EAE affected mice
por: Zilkha-Falb, Rina, et al.
Publicado: (2020)

Auranofin Modulates Thioredoxin Reductase/Nrf2 Signaling in Peripheral Immune Cells and the CNS in a Mouse Model of Relapsing–Remitting EAE
por: Al-Kharashi, Layla A., et al.
Publicado: (2023)

Comprehensive Analysis of the Immune and Stromal Compartments of the CNS in EAE Mice Reveal Pathways by Which Chloroquine Suppresses Neuroinflammation
por: Thome, Rodolfo, et al.
Publicado: (2020)

Targeted Expression of Myelin Autoantigen in the Periphery Induces Antigen-Specific T and B Cell Tolerance and Ameliorates Autoimmune Disease
por: Na, Shin-Young, et al.
Publicado: (2021)

Combining Adoptive Treg Transfer with Bone Marrow Transplantation for Transplantation Tolerance
por: Pilat, Nina, et al.
Publicado: (2017)

Effector Tregs: middle-men in TGFβ activation
por: Worthington, John J., et al.
Publicado: (2015)

Chemokine receptor expression by inflammatory T cells in EAE
por: Mony, Jyothi Thyagabhavan, et al.
Publicado: (2014)

Notch Signaling and T-Helper Cells in EAE/MS
por: Bassil, Ribal, et al.
Publicado: (2013)

Tolerogenic Vaccination Reduced Effector Memory CD4 T Cells and Induced Effector Memory Treg Cells for Type I Diabetes Treatment
por: Zhang, Jingyao, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_rnqtrfnod463851mk79piqnu9b