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Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier

BACKGROUND: TP53 and BRCA1/2 mutations are the main drivers in high-grade serous ovarian carcinoma (HGSOC). We hypothesise that combining tissue phenotypes from image analysis of tumour sections with genomic profiles could reveal other significant driver events. RESULTS: Automatic estimates of strom...

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Detalles Bibliográficos
Autores principales:	Martins, Filipe C, Santiago, Ines de, Trinh, Anne, Xian, Jian, Guo, Anne, Sayal, Karen, Jimenez-Linan, Mercedes, Deen, Suha, Driver, Kristy, Mack, Marie, Aslop, Jennifer, Pharoah, Paul D, Markowetz, Florian, Brenton, James D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268857/ https://www.ncbi.nlm.nih.gov/pubmed/25608477 http://dx.doi.org/10.1186/s13059-014-0526-8

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