Structural insights into 5′ flap DNA unwinding and incision by the human FAN1 dimer

Human FANCD2-associated nuclease 1 (FAN1) is a DNA structure-specific nuclease involved in the processing of DNA interstrand crosslinks (ICLs). FAN1 maintains genomic stability and prevents tissue decline in multiple organs, yet it confers ICL-induced anti-cancer drug resistance in several cancer su...

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Detalles Bibliográficos
Autores principales: Zhao, Qi, Xue, Xiaoyu, Longerich, Simonne, Sung, Patrick, Xiong, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268874/
https://www.ncbi.nlm.nih.gov/pubmed/25500724
http://dx.doi.org/10.1038/ncomms6726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268874/
https://www.ncbi.nlm.nih.gov/pubmed/25500724
http://dx.doi.org/10.1038/ncomms6726

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