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Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat
The emerging H5 clade 2.3.4.6 viruses of different NA subtypes have been detected in different domestic poultry in China. We evaluated the receptor binding property and transmissibility of four novel H5 clade 2.3.4.6 subtype highly pathogenic avian influenza viruses. The results show that these viru...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268885/ https://www.ncbi.nlm.nih.gov/pubmed/25516306 http://dx.doi.org/10.1186/s13567-014-0127-2 |
| _version_ | 1782349305948930048 |
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| author | Li, Qunhui Wang, Xuan Gu, Min Zhu, Jie Hao, Xiaoli Gao, Zhao Sun, Zhongtao Hu, Jiao Hu, Shunlin Wang, Xiaoquan Liu, Xiaowen Liu, Xiufan |
| author_facet | Li, Qunhui Wang, Xuan Gu, Min Zhu, Jie Hao, Xiaoli Gao, Zhao Sun, Zhongtao Hu, Jiao Hu, Shunlin Wang, Xiaoquan Liu, Xiaowen Liu, Xiufan |
| author_sort | Li, Qunhui |
| collection | PubMed |
| description | The emerging H5 clade 2.3.4.6 viruses of different NA subtypes have been detected in different domestic poultry in China. We evaluated the receptor binding property and transmissibility of four novel H5 clade 2.3.4.6 subtype highly pathogenic avian influenza viruses. The results show that these viruses bound to both avian-type (α-2,3) and human-type (α-2,6) receptors. Furthermore, we found that one of these viruses, GS/EC/1112/11, not only replicated but also transmitted efficiently in guinea pigs. Therefore, such novel H5 subtype viruses have the potential of a pandemic threat. |
| format | Online Article Text |
| id | pubmed-4268885 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-42688852014-12-17 Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat Li, Qunhui Wang, Xuan Gu, Min Zhu, Jie Hao, Xiaoli Gao, Zhao Sun, Zhongtao Hu, Jiao Hu, Shunlin Wang, Xiaoquan Liu, Xiaowen Liu, Xiufan Vet Res Short Report The emerging H5 clade 2.3.4.6 viruses of different NA subtypes have been detected in different domestic poultry in China. We evaluated the receptor binding property and transmissibility of four novel H5 clade 2.3.4.6 subtype highly pathogenic avian influenza viruses. The results show that these viruses bound to both avian-type (α-2,3) and human-type (α-2,6) receptors. Furthermore, we found that one of these viruses, GS/EC/1112/11, not only replicated but also transmitted efficiently in guinea pigs. Therefore, such novel H5 subtype viruses have the potential of a pandemic threat. BioMed Central 2014-12-17 2014 /pmc/articles/PMC4268885/ /pubmed/25516306 http://dx.doi.org/10.1186/s13567-014-0127-2 Text en © Li et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Short Report Li, Qunhui Wang, Xuan Gu, Min Zhu, Jie Hao, Xiaoli Gao, Zhao Sun, Zhongtao Hu, Jiao Hu, Shunlin Wang, Xiaoquan Liu, Xiaowen Liu, Xiufan Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat |
| title | Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat |
| title_full | Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat |
| title_fullStr | Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat |
| title_full_unstemmed | Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat |
| title_short | Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat |
| title_sort | novel h5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat |
| topic | Short Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268885/ https://www.ncbi.nlm.nih.gov/pubmed/25516306 http://dx.doi.org/10.1186/s13567-014-0127-2 |
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