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Over-expression of beclin-1 in gallbladder carcinoma and its relationship with prognosis
AIM OF THE STUDY: We determined the expression of beclin-1 in gallbladder carcinoma, analyzed the association of beclin-1 expression with clinicopathologic parameters and prognosis, and investigated the relationship between microvessel density and beclin-1 expression. MATERIAL AND METHODS: Tissue mi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268994/ https://www.ncbi.nlm.nih.gov/pubmed/25520576 http://dx.doi.org/10.5114/wo.2014.41395 |
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author | Chen, Yigang Yan, Jun Yu, Song Wang, Xiaohu Zheng, Qi |
author_facet | Chen, Yigang Yan, Jun Yu, Song Wang, Xiaohu Zheng, Qi |
author_sort | Chen, Yigang |
collection | PubMed |
description | AIM OF THE STUDY: We determined the expression of beclin-1 in gallbladder carcinoma, analyzed the association of beclin-1 expression with clinicopathologic parameters and prognosis, and investigated the relationship between microvessel density and beclin-1 expression. MATERIAL AND METHODS: Tissue microarray blocks containing 118 primary gallbladder tumor sites were used. Clinical parameters and prognostic data were collected. Expression of beclin-1 in these specimens was analyzed by immunohistochemical studies and confirmed by Western blotting. Microvessel density was counted using immunohistochemical staining. RESULTS: The overall rate of over-expression of beclin-1 was 68.1% (80 of 118). Over-expression of beclin-1 was significantly associated with TNM stage and liver metastasis. Over-expression of beclin-1 has no significant relationship with age, sex, lymphatic metastasis, or tumor differentiation. Based on the Kaplan-Meier method, over-expression of beclin-1 showed no significant difference for the overall survival rate in patients with gallbladder cancer. The multivariate Cox regression analysis demonstrated that beclin-1 was not an independent prognostic factor for gallbladder cancer. CONCLUSIONS: Beclin-1 might play roles in the development of gallbladder cancer. However, beclin-1 may not be an effective prognostic factor for gallbladder cancer. |
format | Online Article Text |
id | pubmed-4268994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-42689942014-12-17 Over-expression of beclin-1 in gallbladder carcinoma and its relationship with prognosis Chen, Yigang Yan, Jun Yu, Song Wang, Xiaohu Zheng, Qi Contemp Oncol (Pozn) Original Paper AIM OF THE STUDY: We determined the expression of beclin-1 in gallbladder carcinoma, analyzed the association of beclin-1 expression with clinicopathologic parameters and prognosis, and investigated the relationship between microvessel density and beclin-1 expression. MATERIAL AND METHODS: Tissue microarray blocks containing 118 primary gallbladder tumor sites were used. Clinical parameters and prognostic data were collected. Expression of beclin-1 in these specimens was analyzed by immunohistochemical studies and confirmed by Western blotting. Microvessel density was counted using immunohistochemical staining. RESULTS: The overall rate of over-expression of beclin-1 was 68.1% (80 of 118). Over-expression of beclin-1 was significantly associated with TNM stage and liver metastasis. Over-expression of beclin-1 has no significant relationship with age, sex, lymphatic metastasis, or tumor differentiation. Based on the Kaplan-Meier method, over-expression of beclin-1 showed no significant difference for the overall survival rate in patients with gallbladder cancer. The multivariate Cox regression analysis demonstrated that beclin-1 was not an independent prognostic factor for gallbladder cancer. CONCLUSIONS: Beclin-1 might play roles in the development of gallbladder cancer. However, beclin-1 may not be an effective prognostic factor for gallbladder cancer. Termedia Publishing House 2014-06-18 2014 /pmc/articles/PMC4268994/ /pubmed/25520576 http://dx.doi.org/10.5114/wo.2014.41395 Text en Copyright © 2014 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Chen, Yigang Yan, Jun Yu, Song Wang, Xiaohu Zheng, Qi Over-expression of beclin-1 in gallbladder carcinoma and its relationship with prognosis |
title | Over-expression of beclin-1 in gallbladder carcinoma and its relationship with prognosis |
title_full | Over-expression of beclin-1 in gallbladder carcinoma and its relationship with prognosis |
title_fullStr | Over-expression of beclin-1 in gallbladder carcinoma and its relationship with prognosis |
title_full_unstemmed | Over-expression of beclin-1 in gallbladder carcinoma and its relationship with prognosis |
title_short | Over-expression of beclin-1 in gallbladder carcinoma and its relationship with prognosis |
title_sort | over-expression of beclin-1 in gallbladder carcinoma and its relationship with prognosis |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268994/ https://www.ncbi.nlm.nih.gov/pubmed/25520576 http://dx.doi.org/10.5114/wo.2014.41395 |
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