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THE CDC13-STN1-TEN1 COMPLEX STIMULATES POL α ACTIVITY BY PROMOTING RNA PRIMING AND PRIMASE-TO-POLYMERASE SWITCH
Emerging evidence suggests that Cdc13-Stn1-Ten1 (CST), an RPA-like ssDNA-binding complex, may regulate primase-Pol α (PP) activity at telomeres constitutively, and at other genomic locations under conditions of replication stress. Here we examine the mechanisms of PP stimulation by CST using purifie...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269169/ https://www.ncbi.nlm.nih.gov/pubmed/25503194 http://dx.doi.org/10.1038/ncomms6762 |