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TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein
The TRIM37 (or MUL) gene is located in the 17q23 chromosomal region, which is amplified in up to ~40% of breast cancers(1). TRIM37 contains a RING finger domain, a hallmark of E3 ubiquitin ligases(2), but its protein substrate(s) is unknown. Here we report that TRIM37 mono-ubiquitinates histone H2A,...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269325/ https://www.ncbi.nlm.nih.gov/pubmed/25470042 http://dx.doi.org/10.1038/nature13955 |