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Covalent Adduct Formation between the Antihypertensive Drug Hydralazine and Abasic Sites in Double- and Single-Stranded DNA

[Image: see text] Hydralazine (4) is an antihypertensive agent that displays both mutagenic and epigenetic properties. Here, gel electrophoretic, mass spectroscopic, and chemical kinetics methods were used to provide evidence that medicinally relevant concentrations of 4 rapidly form covalent adduct...

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Detalles Bibliográficos
Autores principales:	Melton, Douglas, Lewis, Calvin D., Price, Nathan E., Gates, Kent S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269403/ https://www.ncbi.nlm.nih.gov/pubmed/25405892 http://dx.doi.org/10.1021/tx5003657

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