Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus

Virus-like particles (VLPs) composed of the truncated capsid protein of swine hepatitis E virus (HEV) were developed and immune responses of mice immunized with the VLPs were evaluated. IgG titers specific for the capsid protein of swine HEV were significantly higher for all groups of mice immunized...

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Detalles Bibliográficos
Autores principales: Song, Young-Jo, Park, Woo-Jung, Lee, Seul-Kee, Lee, Joong-Bok, Park, Seung-Yong, Song, Chang-Seon, Lee, Sang-Won, Seo, Kun-Ho, Kang, Young-Sun, Song, Jae-Young, Choi, In-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269602/
https://www.ncbi.nlm.nih.gov/pubmed/24690608
http://dx.doi.org/10.4142/jvs.2014.15.4.575
Descripción
Sumario:Virus-like particles (VLPs) composed of the truncated capsid protein of swine hepatitis E virus (HEV) were developed and immune responses of mice immunized with the VLPs were evaluated. IgG titers specific for the capsid protein of swine HEV were significantly higher for all groups of mice immunized with the VLPs than those of the negative control mice. Splenocytes from mice immunized with the VLPs also produced significantly greater quantities of interferon (IFN)-γ than interleukin (IL)-4 and IL-10. These newly developed swine HEV VLPs have the capacity to induce antigen-specific antibody and IFN-γ production in immunized mice.

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