Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus

Virus-like particles (VLPs) composed of the truncated capsid protein of swine hepatitis E virus (HEV) were developed and immune responses of mice immunized with the VLPs were evaluated. IgG titers specific for the capsid protein of swine HEV were significantly higher for all groups of mice immunized...

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Autores principales: Song, Young-Jo, Park, Woo-Jung, Lee, Seul-Kee, Lee, Joong-Bok, Park, Seung-Yong, Song, Chang-Seon, Lee, Sang-Won, Seo, Kun-Ho, Kang, Young-Sun, Song, Jae-Young, Choi, In-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269602/
https://www.ncbi.nlm.nih.gov/pubmed/24690608
http://dx.doi.org/10.4142/jvs.2014.15.4.575
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author Song, Young-Jo
Park, Woo-Jung
Lee, Seul-Kee
Lee, Joong-Bok
Park, Seung-Yong
Song, Chang-Seon
Lee, Sang-Won
Seo, Kun-Ho
Kang, Young-Sun
Song, Jae-Young
Choi, In-Soo
author_facet Song, Young-Jo
Park, Woo-Jung
Lee, Seul-Kee
Lee, Joong-Bok
Park, Seung-Yong
Song, Chang-Seon
Lee, Sang-Won
Seo, Kun-Ho
Kang, Young-Sun
Song, Jae-Young
Choi, In-Soo
author_sort Song, Young-Jo
collection PubMed
description Virus-like particles (VLPs) composed of the truncated capsid protein of swine hepatitis E virus (HEV) were developed and immune responses of mice immunized with the VLPs were evaluated. IgG titers specific for the capsid protein of swine HEV were significantly higher for all groups of mice immunized with the VLPs than those of the negative control mice. Splenocytes from mice immunized with the VLPs also produced significantly greater quantities of interferon (IFN)-γ than interleukin (IL)-4 and IL-10. These newly developed swine HEV VLPs have the capacity to induce antigen-specific antibody and IFN-γ production in immunized mice.
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spelling pubmed-42696022014-12-19 Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus Song, Young-Jo Park, Woo-Jung Lee, Seul-Kee Lee, Joong-Bok Park, Seung-Yong Song, Chang-Seon Lee, Sang-Won Seo, Kun-Ho Kang, Young-Sun Song, Jae-Young Choi, In-Soo J Vet Sci Short Communication Virus-like particles (VLPs) composed of the truncated capsid protein of swine hepatitis E virus (HEV) were developed and immune responses of mice immunized with the VLPs were evaluated. IgG titers specific for the capsid protein of swine HEV were significantly higher for all groups of mice immunized with the VLPs than those of the negative control mice. Splenocytes from mice immunized with the VLPs also produced significantly greater quantities of interferon (IFN)-γ than interleukin (IL)-4 and IL-10. These newly developed swine HEV VLPs have the capacity to induce antigen-specific antibody and IFN-γ production in immunized mice. The Korean Society of Veterinary Science 2014-12 2014-12-15 /pmc/articles/PMC4269602/ /pubmed/24690608 http://dx.doi.org/10.4142/jvs.2014.15.4.575 Text en © 2014 The Korean Society of Veterinary Science. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Song, Young-Jo
Park, Woo-Jung
Lee, Seul-Kee
Lee, Joong-Bok
Park, Seung-Yong
Song, Chang-Seon
Lee, Sang-Won
Seo, Kun-Ho
Kang, Young-Sun
Song, Jae-Young
Choi, In-Soo
Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus
title Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus
title_full Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus
title_fullStr Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus
title_full_unstemmed Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus
title_short Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus
title_sort induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis e virus
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269602/
https://www.ncbi.nlm.nih.gov/pubmed/24690608
http://dx.doi.org/10.4142/jvs.2014.15.4.575
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