Cargando…

A Bad Case of Good’s Syndrome

Good’s syndrome is a relatively rare immunodeficiency condition that presents in the fourth or fifth decade of life and is defined by hypogammaglobulinemia in the setting of a thymoma. The humoral defect may be severe enough to cause an absence in B cells, with a consequent recurrence of sinopulmona...

Descripción completa

Detalles Bibliográficos
Autores principales: Tachdjian, Raffi, Keller, Janet J., Pfeffer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269629/
https://www.ncbi.nlm.nih.gov/pubmed/25287948
http://dx.doi.org/10.1007/s40121-014-0045-7
_version_ 1782349381840666624
author Tachdjian, Raffi
Keller, Janet J.
Pfeffer, Michael
author_facet Tachdjian, Raffi
Keller, Janet J.
Pfeffer, Michael
author_sort Tachdjian, Raffi
collection PubMed
description Good’s syndrome is a relatively rare immunodeficiency condition that presents in the fourth or fifth decade of life and is defined by hypogammaglobulinemia in the setting of a thymoma. The humoral defect may be severe enough to cause an absence in B cells, with a consequent recurrence of sinopulmonary disease, chronic non-infectious diarrhea and opportunistic infections. The prognosis in patients with Good’s syndrome appears to be worse than in those with X-linked agammaglobulinemia (XLA) and common variable immune deficiency (CVID). There have only been three cases of Good’s syndrome associated with mycobacterium, and only one case with a cavitary lesion in the lungs. We present here a unique case of Good’s syndrome with a non-mycobacterial cavitary lesion. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40121-014-0045-7) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-4269629
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Springer Healthcare
record_format MEDLINE/PubMed
spelling pubmed-42696292014-12-19 A Bad Case of Good’s Syndrome Tachdjian, Raffi Keller, Janet J. Pfeffer, Michael Infect Dis Ther Case Report Good’s syndrome is a relatively rare immunodeficiency condition that presents in the fourth or fifth decade of life and is defined by hypogammaglobulinemia in the setting of a thymoma. The humoral defect may be severe enough to cause an absence in B cells, with a consequent recurrence of sinopulmonary disease, chronic non-infectious diarrhea and opportunistic infections. The prognosis in patients with Good’s syndrome appears to be worse than in those with X-linked agammaglobulinemia (XLA) and common variable immune deficiency (CVID). There have only been three cases of Good’s syndrome associated with mycobacterium, and only one case with a cavitary lesion in the lungs. We present here a unique case of Good’s syndrome with a non-mycobacterial cavitary lesion. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40121-014-0045-7) contains supplementary material, which is available to authorized users. Springer Healthcare 2014-10-07 2014-12 /pmc/articles/PMC4269629/ /pubmed/25287948 http://dx.doi.org/10.1007/s40121-014-0045-7 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Case Report
Tachdjian, Raffi
Keller, Janet J.
Pfeffer, Michael
A Bad Case of Good’s Syndrome
title A Bad Case of Good’s Syndrome
title_full A Bad Case of Good’s Syndrome
title_fullStr A Bad Case of Good’s Syndrome
title_full_unstemmed A Bad Case of Good’s Syndrome
title_short A Bad Case of Good’s Syndrome
title_sort bad case of good’s syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269629/
https://www.ncbi.nlm.nih.gov/pubmed/25287948
http://dx.doi.org/10.1007/s40121-014-0045-7
work_keys_str_mv AT tachdjianraffi abadcaseofgoodssyndrome
AT kellerjanetj abadcaseofgoodssyndrome
AT pfeffermichael abadcaseofgoodssyndrome
AT tachdjianraffi badcaseofgoodssyndrome
AT kellerjanetj badcaseofgoodssyndrome
AT pfeffermichael badcaseofgoodssyndrome