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Functional fission of parvalbumin interneuron classes during fast network events
Fast spiking, parvalbumin (PV) expressing hippocampal interneurons are classified into basket, axo-axonic (chandelier), and bistratified cells. These cell classes play key roles in regulating local circuit operations and rhythmogenesis by releasing GABA in precise temporal patterns onto distinct dom...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270094/ https://www.ncbi.nlm.nih.gov/pubmed/25375253 http://dx.doi.org/10.7554/eLife.04006 |
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author | Varga, Csaba Oijala, Mikko Lish, Jonathan Szabo, Gergely G Bezaire, Marianne Marchionni, Ivan Golshani, Peyman Soltesz, Ivan |
author_facet | Varga, Csaba Oijala, Mikko Lish, Jonathan Szabo, Gergely G Bezaire, Marianne Marchionni, Ivan Golshani, Peyman Soltesz, Ivan |
author_sort | Varga, Csaba |
collection | PubMed |
description | Fast spiking, parvalbumin (PV) expressing hippocampal interneurons are classified into basket, axo-axonic (chandelier), and bistratified cells. These cell classes play key roles in regulating local circuit operations and rhythmogenesis by releasing GABA in precise temporal patterns onto distinct domains of principal cells. In this study, we show that each of the three major PV cell classes further splits into functionally distinct sub-classes during fast network events in vivo. During the slower (<10 Hz) theta oscillations, each cell class exhibited its own characteristic, relatively uniform firing behavior. However, during faster (>90 Hz) oscillations, within-class differences in PV interneuron discharges emerged, which segregated along specific features of dendritic structure or somatic location. Functional divergence of PV sub-classes during fast but not slow network oscillations effectively doubles the repertoire of spatio-temporal patterns of GABA release available for rapid circuit operations. DOI: http://dx.doi.org/10.7554/eLife.04006.001 |
format | Online Article Text |
id | pubmed-4270094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42700942015-01-29 Functional fission of parvalbumin interneuron classes during fast network events Varga, Csaba Oijala, Mikko Lish, Jonathan Szabo, Gergely G Bezaire, Marianne Marchionni, Ivan Golshani, Peyman Soltesz, Ivan eLife Neuroscience Fast spiking, parvalbumin (PV) expressing hippocampal interneurons are classified into basket, axo-axonic (chandelier), and bistratified cells. These cell classes play key roles in regulating local circuit operations and rhythmogenesis by releasing GABA in precise temporal patterns onto distinct domains of principal cells. In this study, we show that each of the three major PV cell classes further splits into functionally distinct sub-classes during fast network events in vivo. During the slower (<10 Hz) theta oscillations, each cell class exhibited its own characteristic, relatively uniform firing behavior. However, during faster (>90 Hz) oscillations, within-class differences in PV interneuron discharges emerged, which segregated along specific features of dendritic structure or somatic location. Functional divergence of PV sub-classes during fast but not slow network oscillations effectively doubles the repertoire of spatio-temporal patterns of GABA release available for rapid circuit operations. DOI: http://dx.doi.org/10.7554/eLife.04006.001 eLife Sciences Publications, Ltd 2014-11-06 /pmc/articles/PMC4270094/ /pubmed/25375253 http://dx.doi.org/10.7554/eLife.04006 Text en © 2014, Varga et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Varga, Csaba Oijala, Mikko Lish, Jonathan Szabo, Gergely G Bezaire, Marianne Marchionni, Ivan Golshani, Peyman Soltesz, Ivan Functional fission of parvalbumin interneuron classes during fast network events |
title | Functional fission of parvalbumin interneuron classes during fast network events |
title_full | Functional fission of parvalbumin interneuron classes during fast network events |
title_fullStr | Functional fission of parvalbumin interneuron classes during fast network events |
title_full_unstemmed | Functional fission of parvalbumin interneuron classes during fast network events |
title_short | Functional fission of parvalbumin interneuron classes during fast network events |
title_sort | functional fission of parvalbumin interneuron classes during fast network events |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270094/ https://www.ncbi.nlm.nih.gov/pubmed/25375253 http://dx.doi.org/10.7554/eLife.04006 |
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