TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

SHARPIN regulates immune signaling and contributes to full transcriptional activity and prevention of cell death in response to TNF in vitro. The inactivating mouse Sharpin cpdm mutation causes TNF-dependent multi-organ inflammation, characterized by dermatitis, liver inflammation, splenomegaly, and...

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Detalles Bibliográficos
Autores principales: Rickard, James A, Anderton, Holly, Etemadi, Nima, Nachbur, Ueli, Darding, Maurice, Peltzer, Nieves, Lalaoui, Najoua, Lawlor, Kate E, Vanyai, Hannah, Hall, Cathrine, Bankovacki, Aleks, Gangoda, Lahiru, Wong, Wendy Wei-Lynn, Corbin, Jason, Huang, Chunzi, Mocarski, Edward S, Murphy, James M, Alexander, Warren S, Voss, Anne K, Vaux, David L, Kaiser, William J, Walczak, Henning, Silke, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270099/
https://www.ncbi.nlm.nih.gov/pubmed/25443632
http://dx.doi.org/10.7554/eLife.03464

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