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Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity

It has been established that vagal nerve stimulation (VNS) benefits patients and/or animals with heart failure. However, the impact of VNS on sympathetic nerve activity (SNA) remains unknown. In this study, we investigated how vagal afferent stimulation (AVNS) impacts baroreflex control of SNA. In 1...

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Autores principales: Saku, Keita, Kishi, Takuya, Sakamoto, Kazuo, Hosokawa, Kazuya, Sakamoto, Takafumi, Murayama, Yoshinori, Kakino, Takamori, Ikeda, Masataka, Ide, Tomomi, Sunagawa, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270242/
https://www.ncbi.nlm.nih.gov/pubmed/25194023
http://dx.doi.org/10.14814/phy2.12136
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author Saku, Keita
Kishi, Takuya
Sakamoto, Kazuo
Hosokawa, Kazuya
Sakamoto, Takafumi
Murayama, Yoshinori
Kakino, Takamori
Ikeda, Masataka
Ide, Tomomi
Sunagawa, Kenji
author_facet Saku, Keita
Kishi, Takuya
Sakamoto, Kazuo
Hosokawa, Kazuya
Sakamoto, Takafumi
Murayama, Yoshinori
Kakino, Takamori
Ikeda, Masataka
Ide, Tomomi
Sunagawa, Kenji
author_sort Saku, Keita
collection PubMed
description It has been established that vagal nerve stimulation (VNS) benefits patients and/or animals with heart failure. However, the impact of VNS on sympathetic nerve activity (SNA) remains unknown. In this study, we investigated how vagal afferent stimulation (AVNS) impacts baroreflex control of SNA. In 12 anesthetized Sprague–Dawley rats, we controlled the pressure in isolated bilateral carotid sinuses (CSP), and measured splanchnic SNA and arterial pressure (AP). Under a constant CSP, increasing the voltage of AVNS dose dependently decreased SNA and AP. The averaged maximal inhibition of SNA was ‐28.0 ± 10.3%. To evaluate the dynamic impacts of AVNS on SNA, we performed random AVNS using binary white noise sequences, and identified the transfer function from AVNS to SNA and that from SNA to AP. We also identified transfer functions of the native baroreflex from CSP to SNA (neural arc) and from SNA to AP (peripheral arc). The transfer function from AVNS to SNA strikingly resembled the baroreflex neural arc and the transfer functions of SNA to AP were indistinguishable whether we perturbed ANVS or CSP, indicating that they likely share common central and peripheral neural mechanisms. To examine the impact of AVNS on baroreflex, we changed CSP stepwise and measured SNA and AP responses with or without AVNS. AVNS resets the sigmoidal neural arc downward, but did not affect the linear peripheral arc. In conclusion, AVNS resets the baroreflex neural arc and induces sympathoinhibition in the same manner as the control of SNA and AP by the native baroreflex.
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spelling pubmed-42702422014-12-24 Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity Saku, Keita Kishi, Takuya Sakamoto, Kazuo Hosokawa, Kazuya Sakamoto, Takafumi Murayama, Yoshinori Kakino, Takamori Ikeda, Masataka Ide, Tomomi Sunagawa, Kenji Physiol Rep Original Research It has been established that vagal nerve stimulation (VNS) benefits patients and/or animals with heart failure. However, the impact of VNS on sympathetic nerve activity (SNA) remains unknown. In this study, we investigated how vagal afferent stimulation (AVNS) impacts baroreflex control of SNA. In 12 anesthetized Sprague–Dawley rats, we controlled the pressure in isolated bilateral carotid sinuses (CSP), and measured splanchnic SNA and arterial pressure (AP). Under a constant CSP, increasing the voltage of AVNS dose dependently decreased SNA and AP. The averaged maximal inhibition of SNA was ‐28.0 ± 10.3%. To evaluate the dynamic impacts of AVNS on SNA, we performed random AVNS using binary white noise sequences, and identified the transfer function from AVNS to SNA and that from SNA to AP. We also identified transfer functions of the native baroreflex from CSP to SNA (neural arc) and from SNA to AP (peripheral arc). The transfer function from AVNS to SNA strikingly resembled the baroreflex neural arc and the transfer functions of SNA to AP were indistinguishable whether we perturbed ANVS or CSP, indicating that they likely share common central and peripheral neural mechanisms. To examine the impact of AVNS on baroreflex, we changed CSP stepwise and measured SNA and AP responses with or without AVNS. AVNS resets the sigmoidal neural arc downward, but did not affect the linear peripheral arc. In conclusion, AVNS resets the baroreflex neural arc and induces sympathoinhibition in the same manner as the control of SNA and AP by the native baroreflex. Wiley Periodicals, Inc. 2014-09-04 /pmc/articles/PMC4270242/ /pubmed/25194023 http://dx.doi.org/10.14814/phy2.12136 Text en © 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Saku, Keita
Kishi, Takuya
Sakamoto, Kazuo
Hosokawa, Kazuya
Sakamoto, Takafumi
Murayama, Yoshinori
Kakino, Takamori
Ikeda, Masataka
Ide, Tomomi
Sunagawa, Kenji
Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity
title Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity
title_full Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity
title_fullStr Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity
title_full_unstemmed Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity
title_short Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity
title_sort afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270242/
https://www.ncbi.nlm.nih.gov/pubmed/25194023
http://dx.doi.org/10.14814/phy2.12136
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