Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling

Cholecystokinin (CCK) signaling appears well conserved over evolution. In Drosophila, the CCK-like sulfakinins (DSKs) regulate aspects of gut function, satiety and food ingestion, hyperactivity and aggression, as well as escape-related locomotion and synaptic plasticity during neuromuscular junction...

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Autores principales: Nässel, Dick R., Williams, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270250/
https://www.ncbi.nlm.nih.gov/pubmed/25566191
http://dx.doi.org/10.3389/fendo.2014.00219
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author Nässel, Dick R.
Williams, Michael J.
author_facet Nässel, Dick R.
Williams, Michael J.
author_sort Nässel, Dick R.
collection PubMed
description Cholecystokinin (CCK) signaling appears well conserved over evolution. In Drosophila, the CCK-like sulfakinins (DSKs) regulate aspects of gut function, satiety and food ingestion, hyperactivity and aggression, as well as escape-related locomotion and synaptic plasticity during neuromuscular junction development. Activity in the DSK-producing neurons is regulated by octopamine. We discuss mechanisms behind CCK function in satiety, aggression, and locomotion in some detail and highlight similarities to mammalian CCK signaling.
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spelling pubmed-42702502015-01-06 Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling Nässel, Dick R. Williams, Michael J. Front Endocrinol (Lausanne) Endocrinology Cholecystokinin (CCK) signaling appears well conserved over evolution. In Drosophila, the CCK-like sulfakinins (DSKs) regulate aspects of gut function, satiety and food ingestion, hyperactivity and aggression, as well as escape-related locomotion and synaptic plasticity during neuromuscular junction development. Activity in the DSK-producing neurons is regulated by octopamine. We discuss mechanisms behind CCK function in satiety, aggression, and locomotion in some detail and highlight similarities to mammalian CCK signaling. Frontiers Media S.A. 2014-12-18 /pmc/articles/PMC4270250/ /pubmed/25566191 http://dx.doi.org/10.3389/fendo.2014.00219 Text en Copyright © 2014 Nässel and Williams. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Nässel, Dick R.
Williams, Michael J.
Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling
title Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling
title_full Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling
title_fullStr Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling
title_full_unstemmed Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling
title_short Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling
title_sort cholecystokinin-like peptide (dsk) in drosophila, not only for satiety signaling
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270250/
https://www.ncbi.nlm.nih.gov/pubmed/25566191
http://dx.doi.org/10.3389/fendo.2014.00219
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