Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia

KEY CLINICAL MESSAGE: Gene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hemat...

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Detalles Bibliográficos
Autores principales: Xiang, Zhifu, Kaur, Varinder, Aburiziq, Ibrahim K, Mehta, Paulette, Emanuel, Peter, Schichman, Steven A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270708/
https://www.ncbi.nlm.nih.gov/pubmed/25548628
http://dx.doi.org/10.1002/ccr3.110
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author Xiang, Zhifu
Kaur, Varinder
Aburiziq, Ibrahim K
Mehta, Paulette
Emanuel, Peter
Schichman, Steven A
author_facet Xiang, Zhifu
Kaur, Varinder
Aburiziq, Ibrahim K
Mehta, Paulette
Emanuel, Peter
Schichman, Steven A
author_sort Xiang, Zhifu
collection PubMed
description KEY CLINICAL MESSAGE: Gene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hematologic malignancies, and to identify the potential targets for therapy.
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spelling pubmed-42707082014-12-29 Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia Xiang, Zhifu Kaur, Varinder Aburiziq, Ibrahim K Mehta, Paulette Emanuel, Peter Schichman, Steven A Clin Case Rep Case Reports KEY CLINICAL MESSAGE: Gene panel sequencing in a CMML patient without any detectable genetic abnormality by conventional genetic studies identified four concurrent somatic mutations in three genes. Gene panel mutation analysis is a rapidly emerging clinical tool to demonstrate the clonality in hematologic malignancies, and to identify the potential targets for therapy. Blackwell Publishing Ltd 2014-12 2014-11-13 /pmc/articles/PMC4270708/ /pubmed/25548628 http://dx.doi.org/10.1002/ccr3.110 Text en © 2014 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Xiang, Zhifu
Kaur, Varinder
Aburiziq, Ibrahim K
Mehta, Paulette
Emanuel, Peter
Schichman, Steven A
Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia
title Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia
title_full Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia
title_fullStr Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia
title_full_unstemmed Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia
title_short Natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia
title_sort natural history of chronic myelomonocytic leukemia: gene sequencing identifies multiple clonal molecular abnormalities associated with rapid progression to acute myeloid leukemia
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270708/
https://www.ncbi.nlm.nih.gov/pubmed/25548628
http://dx.doi.org/10.1002/ccr3.110
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